{"id":"W2604751852","doi":"10.1158/1557-3125.dnarepair16-b21","title":"Abstract B21: The selective ATR inhibitor VX-970 enhances the therapeutic effects of standards of care in glioblastoma","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Temozolomide; Cancer research; Medicine; Radiosensitizer; Gene knockdown; DNA damage; Cancer; Neurosphere; Dacarbazine; Pharmacology; Glioblastoma; Radiation therapy; Cell culture; Chemistry; Biology; DNA; Internal medicine; In vitro; Melanoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587543,0.0002351183,0.0002569254,0.0003142174,0.0001506905,0.0004403025,0.0002330212,0.0003178641,0.005313082],"category_scores_gemma":[0.000141437,0.00009544795,0.0002413954,0.0001899739,0.0001436845,0.0002193228,0.0002555185,0.0005875374,0.0007249474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004879799,"about_ca_system_score_gemma":0.0004262501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195399,"about_ca_topic_score_gemma":0.001825532,"domain_scores_codex":[0.9999079,0.00001372434,0.000008777827,0.00001342803,0.00002902281,0.00002721604],"domain_scores_gemma":[0.9999446,0.000006847502,0.00001404061,0.000004522946,0.000009289372,0.00002064691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0019974,0.0007650091,0.000630111,0.0002545483,0.00004124288,0.0001680515,0.00004493944,0.0002947731,0.939872,0.0005486204,0.002007188,0.05337613],"study_design_scores_gemma":[0.0003546418,0.009934372,0.02141265,0.00004982843,0.0001183956,0.001012979,0.00009281147,0.001681107,0.946164,0.000180353,0.01898374,0.00001512314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837531,0.006144801,0.001113091,0.0005905026,0.000135497,0.00007647883,0.0004071667,0.0001763742,0.00760318],"genre_scores_gemma":[0.9905895,0.003549928,0.0008959075,0.0001145588,0.00002392535,0.00003129006,0.0005389358,0.00002489437,0.004230946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005313082,"threshold_uncertainty_score":0.01777399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282811545247069,"score_gpt":0.3602496580728859,"score_spread":0.3474215426204152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}