{"id":"W2604758481","doi":"10.1021/acs.nanolett.7b00814","title":"A DNA Nanodevice That Loads and Releases a Cargo with Hemoglobin-Like Allosteric Control and Cooperativity","year":2017,"lang":"en","type":"article","venue":"Nano Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; H2020 European Research Council; Directorate-General for Research and Innovation; Associazione Italiana per la Ricerca sul Cancro","keywords":"Nanodevice; Allosteric regulation; Cooperativity; Biophysics; Chemistry; Nanotechnology; Rational design; Hemoglobin; Protein engineering; DNA; Synthetic biology; Computational biology; Materials science; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631651,0.0002236297,0.0001845481,0.000117603,0.0001430813,0.0003449048,0.0003032118,0.0004073172,0.0006446719],"category_scores_gemma":[0.0002928073,0.0001495117,0.0002117662,0.00007140669,0.0003170557,0.0003503821,0.0002344063,0.0004419654,0.0003531277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105654,"about_ca_system_score_gemma":0.0002216227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009536789,"about_ca_topic_score_gemma":0.0001705833,"domain_scores_codex":[0.9999013,0.00001298673,0.000009402195,0.000032175,0.00003067374,0.0000134361],"domain_scores_gemma":[0.9998423,0.00005449262,0.00004256,0.0000147439,0.00001606546,0.00002986203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002717625,0.00003008475,0.000183806,0.000127842,0.000009369674,0.00009133552,0.00003464213,0.001078996,0.9901018,0.002404274,0.00008786508,0.005822925],"study_design_scores_gemma":[0.000007532961,0.00009758036,0.0001511576,0.000004952275,0.000006158998,0.0001686956,0.000009365797,0.002138692,0.9915959,0.0001704652,0.005641521,0.000007915048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8165866,0.004392929,0.1662281,0.001195627,0.0004627402,0.0002571681,0.0002882936,0.0005309808,0.01005761],"genre_scores_gemma":[0.8672472,0.001723045,0.1232411,0.0004516345,0.00004311076,0.0001422451,0.0002572442,0.00007058129,0.00682385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006446719,"threshold_uncertainty_score":0.002156675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007326200366157954,"score_gpt":0.2329352411025475,"score_spread":0.2256090407363895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}