{"id":"W2604801416","doi":"10.1158/1557-3125.dnarepair16-pr02","title":"Abstract PR02: Small molecules that specifically inhibit the D-loop activity of RAD51","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RAD51; Homologous recombination; DNA; DNA damage; Biology; Cancer cell; Chemistry; Cell biology; Cancer research; Molecular biology; Biophysics; Cancer; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000908179,0.0005714968,0.0003206909,0.0002654258,0.0001017961,0.0002496504,0.0004519997,0.000348028,0.005047725],"category_scores_gemma":[0.00008750425,0.0001285921,0.0002719754,0.0001726683,0.000137363,0.0002399718,0.0001901678,0.0005901094,0.001929803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101735,"about_ca_system_score_gemma":0.000169062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003102495,"about_ca_topic_score_gemma":0.0003950378,"domain_scores_codex":[0.9999398,0.000007161723,0.000005349451,0.00001798636,0.00001460512,0.0000150808],"domain_scores_gemma":[0.9999655,0.000004841836,0.000007816231,0.000003154286,0.000005724588,0.00001285991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005881812,0.0002241773,0.0001120551,0.0003334061,0.00002498372,0.0001872773,0.00001397669,0.0005185205,0.9689968,0.0009521404,0.001970179,0.0260783],"study_design_scores_gemma":[0.0007952114,0.005276603,0.001412258,0.00003211599,0.00006177904,0.0007747761,0.00001156601,0.00158509,0.9557319,0.0001516947,0.03414101,0.00002604883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8638114,0.04281739,0.02993245,0.0009469417,0.0009637158,0.001048102,0.004065278,0.002391481,0.05402323],"genre_scores_gemma":[0.9500799,0.009849869,0.008871203,0.0007101864,0.00009752378,0.0003786915,0.003614983,0.0000783518,0.02631935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005047725,"threshold_uncertainty_score":0.01688635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0952516193920555,"score_gpt":0.371175248765391,"score_spread":0.2759236293733355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}