{"id":"W2604817598","doi":"10.1016/j.cmet.2017.03.002","title":"Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling","year":2017,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of California, San Francisco; National Institutes of Health; Human Frontier Science Program; National Institute of Diabetes and Digestive and Kidney Diseases; Gladstone Institutes; Canadian Institutes of Health Research; JPB Foundation","keywords":"Thermogenin; Thermogenesis; Mitochondrion; Biology; Endocrinology; Internal medicine; Browning; Cell biology; Inner mitochondrial membrane; White adipose tissue; Adipose tissue; Chemistry; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004834056,0.0005147861,0.001530107,0.0001992717,0.0005862191,0.0001044646,0.0003299477,0.000309009,0.0002555528],"category_scores_gemma":[0.0006820717,0.0004557932,0.000283769,0.0001376534,0.0004896453,0.0004018622,0.0002707656,0.0004197965,0.00004868804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658957,"about_ca_system_score_gemma":0.0001343882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008029995,"about_ca_topic_score_gemma":0.00002394132,"domain_scores_codex":[0.9969934,0.0001867911,0.000860199,0.000768244,0.0005034576,0.0006879058],"domain_scores_gemma":[0.9967082,0.0004378198,0.001013265,0.001053502,0.0003369665,0.0004502841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005045207,0.0003027106,0.002999949,0.0003247015,0.0003163622,0.0001098713,0.004970875,0.000004707458,0.9727078,0.001274409,0.001118767,0.0153653],"study_design_scores_gemma":[0.005468786,0.0001748793,0.05724263,0.00048288,0.0015376,0.00003341607,0.0006737688,0.0001212936,0.9214036,0.001006154,0.0113582,0.0004967392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589009,0.01221439,0.000187015,0.0002102255,0.001206706,0.001091891,0.0001459313,0.00006917088,0.02597371],"genre_scores_gemma":[0.9784262,0.001774303,0.01123007,0.0002673133,0.002464325,0.00004531246,0.00003779946,0.00009814119,0.00565649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05424268,"threshold_uncertainty_score":0.9997894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547288118956822,"score_gpt":0.274048377825771,"score_spread":0.2585754966362028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}