{"id":"W2604831391","doi":"10.1038/ncomms14773","title":"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Ministero dello Sviluppo Economico; Royal Society; Japan Society for the Promotion of Science; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Genome Canada; British Heart Foundation; Wellcome Trust; GlaxoSmithKline; European Commission; Pfizer; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Histone; Peptide; Biochemistry; Chemistry; Cyclic peptide; Lysine; Active site; Arginine; Enzyme; Amino acid; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458921,0.0002701377,0.0001575857,0.00009034498,0.00006596433,0.0001219036,0.000249514,0.0001630893,0.00103152],"category_scores_gemma":[0.0001266462,0.00008283123,0.0001469529,0.00007045191,0.0001235337,0.0001133212,0.0001372451,0.0003323741,0.0002494974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187009,"about_ca_system_score_gemma":0.0001277851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002812891,"about_ca_topic_score_gemma":0.0006892328,"domain_scores_codex":[0.9999251,0.00001052138,0.000005496409,0.0000181571,0.00001953739,0.00002108901],"domain_scores_gemma":[0.9999391,0.00001362062,0.00002037273,0.000006566017,0.000007897079,0.00001241681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001458336,0.00002923269,0.00006532502,0.00005934199,0.00001106223,0.00004289148,0.000007320511,0.0001777823,0.9955598,0.000131997,0.0001105706,0.003658757],"study_design_scores_gemma":[0.00003092747,0.0004969647,0.0005023425,0.000002977119,0.000008199038,0.000126445,0.000004167838,0.0003689091,0.993969,0.00003024261,0.004456036,0.00000393741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762836,0.006713795,0.01067046,0.0001770949,0.0001124943,0.0001450411,0.0005962221,0.0001728678,0.005128416],"genre_scores_gemma":[0.9867328,0.003530533,0.005950819,0.0001114991,0.00002755918,0.00007144933,0.0005256417,0.00002541751,0.003024338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103152,"threshold_uncertainty_score":0.003450751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466130072890793,"score_gpt":0.3442159290582576,"score_spread":0.3295546283293497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}