{"id":"W2604831391","doi":"10.1038/ncomms14773","title":"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Ministero dello Sviluppo Economico; Royal Society; Japan Society for the Promotion of Science; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Genome Canada; British Heart Foundation; Wellcome Trust; GlaxoSmithKline; European Commission; Pfizer; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Histone; Peptide; Biochemistry; Chemistry; Cyclic peptide; Lysine; Active site; Arginine; Enzyme; Amino acid; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927436,0.0000933003,0.000104075,0.00003577655,0.000402971,0.00002641107,0.0005453876,0.0002843222,0.000002649812],"category_scores_gemma":[0.0004709067,0.00009875646,0.0000634608,0.00004719433,0.0002145119,0.000007467456,0.0002475677,0.0002517337,0.000002176976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000297237,"about_ca_system_score_gemma":0.00006118783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007286112,"about_ca_topic_score_gemma":0.0005503039,"domain_scores_codex":[0.9993725,0.0000931966,0.000168313,0.0001574791,0.00008544527,0.0001230187],"domain_scores_gemma":[0.9980611,0.0000457492,0.0002327092,0.001401896,0.0002132868,0.0000452962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001473846,0.00008991452,0.006569149,0.000005628518,0.00003047693,1.845842e-7,0.00004005331,0.000005566303,0.9887462,0.0005332456,0.002149584,0.001815227],"study_design_scores_gemma":[0.0002545525,0.00007733994,0.01717853,0.00001214287,0.00002567351,0.000001936982,0.00001786784,0.00003193479,0.9316261,0.0005884281,0.050076,0.0001095263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736574,0.01899019,0.001079892,0.001118253,0.00005586981,0.0001365333,0.00008886225,0.00001065535,0.004862295],"genre_scores_gemma":[0.9888311,0.003473603,0.006884318,0.0000948095,0.00004813305,0.00002451307,0.0003748508,0.0000147185,0.0002539487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05712016,"threshold_uncertainty_score":0.4027171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466130072890793,"score_gpt":0.3442159290582576,"score_spread":0.3295546283293497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}