{"id":"W2604913935","doi":"10.1158/1557-3125.dnarepair16-a33","title":"Abstract A33: Defect in S phase cell cycle checkpoint renders tumours vulnerable to CHK1 inhibitor single-agent treatment in vitro and in vivo","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CHEK1; Cancer research; Cell cycle checkpoint; In vivo; Melanoma; G2-M DNA damage checkpoint; Cell cycle; DNA damage; Cancer; Biology; Chemistry; DNA; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278244,0.0002650445,0.0002450483,0.0003303725,0.0001528878,0.0001850868,0.0001679177,0.0003516385,0.01021037],"category_scores_gemma":[0.0001192337,0.0001470856,0.0002335132,0.0001235228,0.0001586828,0.0001431064,0.0001007185,0.0009105995,0.001644777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498683,"about_ca_system_score_gemma":0.0001672869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310423,"about_ca_topic_score_gemma":0.00107061,"domain_scores_codex":[0.999879,0.00001406597,0.00001030228,0.00002262895,0.00004142752,0.00003261435],"domain_scores_gemma":[0.999848,0.00004763413,0.00001946139,0.00001803696,0.00001409368,0.00005285934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002731432,0.0001362227,0.000205508,0.00003163395,0.000008460416,0.0001126671,0.00001095607,0.00009941573,0.9959226,0.0001867716,0.001001152,0.002011423],"study_design_scores_gemma":[0.00009933984,0.004007403,0.009368868,0.00002344493,0.00002529162,0.001257404,0.00003978801,0.001500235,0.9772487,0.0001006509,0.006320877,0.000007915686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840049,0.001735045,0.002592479,0.0007632267,0.0002645516,0.0001296879,0.001897838,0.000302544,0.008309804],"genre_scores_gemma":[0.9758999,0.0008390399,0.001947027,0.0002367713,0.00003519627,0.00008305805,0.00239314,0.00009382263,0.01847198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021037,"threshold_uncertainty_score":0.0341571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196025302684574,"score_gpt":0.3633631949764022,"score_spread":0.3214029419495564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}