{"id":"W2604925868","doi":"10.3389/fimmu.2017.00393","title":"Cytokine-Regulation of Na+-K+-Cl− Cotransporter 1 and Cystic Fibrosis Transmembrane Conductance Regulator—Potential Role in Pulmonary Inflammation and Edema Formation","year":2017,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; Regulator; Inflammation; Cystic fibrosis; Cotransporter; Cytokine; Medicine; Chemistry; Immunology; Cell biology; Biology; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002420829,0.0003164002,0.0009222316,0.0003427487,0.00006729253,0.00001637627,0.0001680943,0.0008184123,0.000005408097],"category_scores_gemma":[0.00001462559,0.0003223263,0.0001304835,0.0001018907,0.0002742051,0.00004896426,0.00002420381,0.000185438,4.340086e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003892111,"about_ca_system_score_gemma":0.0000716454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001861671,"about_ca_topic_score_gemma":0.00003906064,"domain_scores_codex":[0.9982837,0.0001258469,0.000821812,0.0004182815,0.0001108509,0.000239518],"domain_scores_gemma":[0.9990368,0.000009532512,0.0005295388,0.000340415,0.00005322435,0.0000305291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005884882,0.0000614622,0.0008799389,0.007697831,0.0001982948,0.000012654,0.0003044278,0.0001186098,0.08958291,0.0001337444,0.00003069066,0.9003909],"study_design_scores_gemma":[0.01074673,0.001369801,0.1199266,0.02368958,0.002339814,0.0009638105,0.0008128365,0.009637516,0.05426218,0.004901601,0.767045,0.004304467],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07408828,0.92062,0.004044865,0.00002052536,0.000411921,0.000690537,0.00007048624,0.000007921018,0.00004549949],"genre_scores_gemma":[0.2959265,0.7015519,0.0004213114,0.000001876934,0.00007447161,0.00006036746,0.001868825,0.0000284798,0.00006631869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8960865,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085343333639571,"score_gpt":0.2367652422626296,"score_spread":0.2259118089262339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}