{"id":"W2604932941","doi":"10.1158/1557-3125.dnarepair16-a26","title":"Abstract A26: High frequency of Cytosine to Adenine mutations in neuroblastoma correlates with genomic aberrations in 8-Oxo-Guanine repair pathway","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"MUTYH; Neuroblastoma; Biology; Guanine; Mutation; Cancer research; DNA glycosylase; Mutation frequency; Molecular biology; DNA repair; Gene; Genetics; Germline mutation; Cell culture; Nucleotide","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003973264,0.0002073447,0.0003878706,0.0008948727,0.0002076011,0.00006001037,0.0003368977,0.00008670815,0.0002476539],"category_scores_gemma":[0.0005055473,0.0001798894,0.00007910069,0.0007348352,0.000298334,0.0001628189,0.0001728436,0.0007329753,0.00006148499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733994,"about_ca_system_score_gemma":0.0008937877,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01001321,"about_ca_topic_score_gemma":0.0116831,"domain_scores_codex":[0.9972795,0.0001402209,0.0004177921,0.000568814,0.0008933467,0.000700341],"domain_scores_gemma":[0.9980841,0.0001119728,0.0001039368,0.0009655443,0.0004061134,0.00032838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001038824,0.000810399,0.1060574,0.0001488079,0.0001192924,0.006839947,0.0003165142,0.0009136432,0.8820094,0.0003476798,0.0001814105,0.001216736],"study_design_scores_gemma":[0.003849368,0.001398985,0.8591329,0.0005396166,0.00001891989,0.00004795696,0.00005641777,0.0001847366,0.1344036,0.0001632017,0.00005182928,0.000152365],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934479,0.0002411862,0.00002442159,0.003122383,0.00004072749,0.001390473,0.00007206033,0.00003301188,0.001627812],"genre_scores_gemma":[0.9979538,0.00005911049,0.0007296251,0.00006587031,0.00003308672,0.0005146255,0.00003480242,0.00006053827,0.0005485117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7530756,"threshold_uncertainty_score":0.9965792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03974112795537701,"score_gpt":0.3679348270553745,"score_spread":0.3281936990999975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}