{"id":"W2604938190","doi":"10.1074/jbc.m116.743997","title":"Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"Wellcome Trust; Wellcome","keywords":"Cysteine; Biochemistry; Transmembrane domain; Pyrimidine; Symporter; Escherichia coli; Nucleoside; Biology; Chemistry; Biophysics; Transporter; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235053,0.0002924148,0.000209014,0.0001922367,0.0002372791,0.00009623905,0.0002071468,0.0002095649,0.0009796097],"category_scores_gemma":[0.0001794378,0.00007450072,0.0002237508,0.0001534162,0.0001770054,0.00008584825,0.0001059647,0.0002865398,0.0001844756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160343,"about_ca_system_score_gemma":0.0001851922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226019,"about_ca_topic_score_gemma":0.002240563,"domain_scores_codex":[0.9999415,0.00001186698,0.000003816821,0.00001623185,0.00001573384,0.00001086306],"domain_scores_gemma":[0.999866,0.00003338808,0.00004045664,0.00002044633,0.00001828876,0.00002153438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005180266,0.000004712593,0.000396839,0.00001409567,0.00000426251,0.00004704647,0.00001498349,0.00003249875,0.9986104,0.00003867229,0.000009482602,0.0007751656],"study_design_scores_gemma":[0.00000745749,0.0002196734,0.01147449,0.000003610346,0.00002088577,0.0007826305,0.0000367959,0.001322102,0.9849932,0.00005357362,0.00108026,0.000005219928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919887,0.0003577149,0.0066995,0.00003150584,0.000006520051,0.00001709124,0.0002181281,0.00005919983,0.0006215262],"genre_scores_gemma":[0.9885548,0.0003312455,0.009431631,0.00002852056,0.000004881154,0.00002642618,0.000655218,0.00002846842,0.0009388559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226019,"threshold_uncertainty_score":0.003277123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02551448376415812,"score_gpt":0.3069686075908085,"score_spread":0.2814541238266504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}