{"id":"W2605117944","doi":"10.1158/1557-3125.dnarepair16-ia03","title":"Abstract IA03: Targeting the DNA damage response to generate new medicines for cancer treatment","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"DNA damage; Cancer; Genome instability; Cancer research; DNA repair; Cancer cell; Synthetic lethality; DNA Damage Repair; Biology; Medicine; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000542134,0.0006523432,0.0004446791,0.0009462807,0.0003248382,0.00170858,0.0007859954,0.0008666604,0.02391308],"category_scores_gemma":[0.0003029714,0.0002480472,0.0004497645,0.0006808171,0.0003619051,0.0007033045,0.0005258507,0.001425795,0.009007012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001969885,"about_ca_system_score_gemma":0.001535756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002935425,"about_ca_topic_score_gemma":0.004941367,"domain_scores_codex":[0.9998239,0.00002626327,0.00001090021,0.00002587417,0.00008148883,0.00003162868],"domain_scores_gemma":[0.9997655,0.00001429894,0.00003528834,0.00001544502,0.000096488,0.00007301211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001061848,0.0004994278,0.0007310389,0.001503899,0.00006977634,0.0004412743,0.00007388571,0.001281685,0.2008709,0.01475586,0.3003344,0.478376],"study_design_scores_gemma":[0.0002861031,0.001310688,0.002949608,0.0003852296,0.0000884872,0.001090108,0.00004455683,0.001381251,0.1170381,0.002897247,0.8724871,0.00004159242],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07838207,0.4425474,0.03437723,0.04800719,0.02721674,0.001405934,0.009119521,0.00403489,0.3549091],"genre_scores_gemma":[0.2140982,0.2683611,0.02353025,0.01379241,0.004341886,0.0003063813,0.006705722,0.0003798764,0.4684842],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02391308,"threshold_uncertainty_score":0.07999724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1617560617625099,"score_gpt":0.5000201570030657,"score_spread":0.3382640952405558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}