{"id":"W2605224781","doi":"10.1111/bcpt.12788","title":"Enrichment of Genetic Variants in the Glucocorticoid Receptor Signalling Pathway in Autoimmune Hepatitis with Failure of Standard Treatment","year":2017,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Alberta Innovates - Health Solutions; Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat","keywords":"Glucocorticoid receptor; Autoimmune hepatitis; Glucocorticoid; Signalling pathways; Receptor; Medicine; Hedgehog signaling pathway; Signal transduction; Pharmacology; Biology; Hepatitis; Immunology; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000241456,0.0001499407,0.0002708547,0.0006885966,0.0002509386,0.0003546439,0.0001566976,0.0003010942,0.001909906],"category_scores_gemma":[0.001196622,0.0001196487,0.0002752432,0.0007773612,0.0002661138,0.0001543653,0.000289237,0.0002210215,0.0001724426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009007385,"about_ca_system_score_gemma":0.00008106521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00068498,"about_ca_topic_score_gemma":0.000715738,"domain_scores_codex":[0.999709,0.00006345367,0.00003719868,0.00009673074,0.00004675693,0.0000469296],"domain_scores_gemma":[0.9993879,0.00017004,0.0002724115,0.00005212678,0.0000417048,0.00007580395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006222419,0.00001546087,0.9908337,0.0000181105,0.00008103994,0.0009963169,0.0001108676,0.00009797159,0.00443942,0.00003838401,0.00005881567,0.002687638],"study_design_scores_gemma":[0.00000635058,0.0000786053,0.9971625,0.000005503474,0.00004449038,0.001947526,0.00009849342,0.0001808808,0.000295437,0.00004386725,0.0001326202,0.00000357288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994919,0.0001833549,0.00009045505,0.000009328694,0.000001672648,0.000002477037,0.00009131773,0.000001913506,0.0001274419],"genre_scores_gemma":[0.9997864,0.00003204939,0.00004448913,0.00000680341,0.000002299716,0.000001428661,0.00008527177,0.000001226297,0.00004007768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909906,"threshold_uncertainty_score":0.00638932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04130088799497677,"score_gpt":0.3621458725706805,"score_spread":0.3208449845757037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}