{"id":"W2605250739","doi":"10.1021/acsmedchemlett.7b00012","title":"Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors","year":2017,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research; Ontario Brain Institute; National Institute of Neurological Disorders and Stroke; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Prodrug; HDAC6; Acetylation; Chemistry; In vivo; Pharmacology; Histone deacetylase; Biochemistry; Histone; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676951,0.0004302701,0.0002838327,0.0001834397,0.000106598,0.0001638459,0.0003634712,0.0002855364,0.001191613],"category_scores_gemma":[0.0001106243,0.0001756039,0.0002389836,0.0001624676,0.0001217023,0.0002019354,0.0001782042,0.0003765049,0.0004192527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083581,"about_ca_system_score_gemma":0.0002067546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000271604,"about_ca_topic_score_gemma":0.0008749356,"domain_scores_codex":[0.9999304,0.00001069481,0.000008155571,0.00001252515,0.00001764568,0.00002068915],"domain_scores_gemma":[0.9999442,0.000005762193,0.00001699891,0.000005517012,0.00001352376,0.00001398734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001549619,0.00009867992,0.0001407002,0.0002075172,0.00001710207,0.000222402,0.00004504688,0.001190643,0.985558,0.000858846,0.0001727904,0.01133323],"study_design_scores_gemma":[0.00009200595,0.001449673,0.0006888382,0.00001301628,0.00002669281,0.0002860948,0.00001727024,0.0009865208,0.9862821,0.0001134272,0.01003196,0.00001239006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515042,0.009784629,0.0282266,0.0002574108,0.0001229841,0.0005695052,0.000783194,0.0001873829,0.008564101],"genre_scores_gemma":[0.9648687,0.007308031,0.02181735,0.0001209946,0.00004031187,0.0002215187,0.0007521276,0.00002272288,0.004848272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191613,"threshold_uncertainty_score":0.003986359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097617402797796,"score_gpt":0.2773365986402645,"score_spread":0.2663604246122865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}