{"id":"W2605264042","doi":"10.1158/1557-3125.dnarepair16-b32","title":"Abstract B32: CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, combined with DDR agents provides a novel approach to increasing therapeutic index","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Olaparib; Camptothecin; PARP inhibitor; Cancer research; PARP1; CHEK1; Pharmacology; Medicine; Cancer; Cell cycle; Cell cycle checkpoint; Biology; Poly ADP ribose polymerase; Internal medicine; Polymerase; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006011749,0.0003928849,0.0001952678,0.0001572321,0.00009259862,0.000238493,0.0002175094,0.0003189958,0.001470817],"category_scores_gemma":[0.00004777171,0.0001088455,0.0001148559,0.0001170663,0.0001230967,0.0001735908,0.0001399631,0.0003687304,0.000493494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003534121,"about_ca_system_score_gemma":0.0001944518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00061153,"about_ca_topic_score_gemma":0.0005801923,"domain_scores_codex":[0.9999378,0.000006585335,0.000003692277,0.00001964305,0.00001924144,0.00001308555],"domain_scores_gemma":[0.9999787,0.000001971683,0.00000754797,0.000001894026,0.000003163498,0.000006719325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008082445,0.00004471065,0.00006983628,0.00003383735,0.000003689691,0.00003894886,0.000004655142,0.0001351901,0.9953798,0.0001174209,0.0001415721,0.003949485],"study_design_scores_gemma":[0.00003000868,0.0005345878,0.0005504836,0.000003280642,0.00000653491,0.0001856693,0.000003491646,0.001033984,0.9943955,0.00001870678,0.003234532,0.000003312363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794664,0.00436994,0.006693833,0.0003236305,0.00008374863,0.000165093,0.0004046517,0.0002733971,0.008219308],"genre_scores_gemma":[0.9921182,0.0007027489,0.003227471,0.00007322964,0.000009442515,0.00003859811,0.0002482722,0.00001682617,0.003565261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470817,"threshold_uncertainty_score":0.004920304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08823895611489224,"score_gpt":0.3694073044102163,"score_spread":0.2811683482953241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}