{"id":"W2605299966","doi":"10.1007/s11357-017-9972-z","title":"A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs","year":2017,"lang":"en","type":"article","venue":"GeroScience","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"National Institute on Aging; National Institutes of Health; University of Washington","keywords":"Medicine; Placebo; Clinical trial; Ejection fraction; Cohort; Mean corpuscular volume; Internal medicine; Randomized controlled trial; Cardiology; Surgery; Heart failure; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001104994,0.0001680886,0.0007719906,0.0001200885,0.000163112,0.0001170565,0.0004510755,0.00008923119,0.000005967068],"category_scores_gemma":[0.002056362,0.0001241165,0.0002456629,0.0001048848,0.0003224778,0.00001211595,0.0002148665,0.00006888402,0.000005799716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003806044,"about_ca_system_score_gemma":0.0001566601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002154629,"about_ca_topic_score_gemma":0.0004506648,"domain_scores_codex":[0.9981923,0.0003523846,0.0003433332,0.0004474173,0.0002991409,0.0003654465],"domain_scores_gemma":[0.9987477,0.0002502721,0.0001007519,0.0006881389,0.00006770017,0.0001454482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3472562,0.000205668,0.001090726,0.00002157215,0.00001964164,0.00001056269,0.000113548,0.00000455232,0.6501853,0.000007591516,0.00001956031,0.001065099],"study_design_scores_gemma":[0.7440955,0.001268904,0.00428359,0.00004792543,0.00002171719,0.000002690712,0.000007289518,0.0001408011,0.2499076,0.00001131038,0.00007530252,0.0001373925],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935783,0.0002177331,0.0001421623,0.00005208938,0.0005360022,0.004923571,0.000005107774,0.000006111533,0.0005389688],"genre_scores_gemma":[0.9978237,0.00006713258,0.0001035962,0.00002496395,0.0000791724,0.0006663969,0.000005113761,0.00001015615,0.001219822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4002778,"threshold_uncertainty_score":0.5061325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03452713418294417,"score_gpt":0.3276758725198635,"score_spread":0.2931487383369193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}