{"id":"W2605301265","doi":"10.1016/j.ebiom.2017.04.004","title":"The iPSC Awakens ANGPTL3 in Tangier Disease","year":2017,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ABCA1; Tangier disease; Induced pluripotent stem cell; ATP Binding Cassette Transporter 1; Biology; ATP-binding cassette transporter; Cell biology; Lipid droplet; Transporter; Genetics; Endocrinology; Gene; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004770149,0.0004524725,0.0008172666,0.000353999,0.0002570769,0.00005775729,0.0005279063,0.0004857124,0.0002933617],"category_scores_gemma":[0.0008774659,0.0002602937,0.0002390723,0.0002331449,0.0007400973,0.00007377259,0.0001205354,0.001681856,0.0002720429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007987945,"about_ca_system_score_gemma":0.000446371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001467769,"about_ca_topic_score_gemma":0.00002710912,"domain_scores_codex":[0.9972144,0.00007926349,0.0004989529,0.0005699873,0.0008488792,0.0007885418],"domain_scores_gemma":[0.9972208,0.0002078059,0.0002539625,0.001901361,0.0001030027,0.0003131252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001188102,0.00004862624,0.002756189,0.0002460849,0.00007242449,0.00296498,0.0001000948,6.220188e-8,0.00002456601,0.00001976815,0.988178,0.005470374],"study_design_scores_gemma":[0.002742012,0.00007337565,0.03862182,0.0005131359,0.0003724162,0.00003834397,0.00005643167,0.000008996655,0.000004012206,0.000273762,0.9570345,0.0002611465],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002025311,0.01534526,0.000005200156,0.9635361,0.003759254,0.0008510873,0.00008564399,0.00007980893,0.01431234],"genre_scores_gemma":[0.006879895,0.00192171,0.00003889048,0.8505279,0.03151658,0.0001467579,0.001583478,0.0001529956,0.1072318],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1130082,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688166843168011,"score_gpt":0.2888935943532751,"score_spread":0.272011925921595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}