{"id":"W2605301265","doi":"10.1016/j.ebiom.2017.04.004","title":"The iPSC Awakens ANGPTL3 in Tangier Disease","year":2017,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ABCA1; Tangier disease; Induced pluripotent stem cell; ATP Binding Cassette Transporter 1; Biology; ATP-binding cassette transporter; Cell biology; Lipid droplet; Transporter; Genetics; Endocrinology; Gene; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066918,0.0003058512,0.0004102409,0.000528826,0.0003405399,0.001064696,0.0004954826,0.00123309,0.004553818],"category_scores_gemma":[0.0005728217,0.0002197052,0.0004000802,0.0002166731,0.0007362349,0.000748637,0.0007955138,0.002761621,0.002232536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918611,"about_ca_system_score_gemma":0.0003213985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857333,"about_ca_topic_score_gemma":0.0004396733,"domain_scores_codex":[0.9997272,0.00005208046,0.00003414511,0.00004353935,0.0001047166,0.00003817504],"domain_scores_gemma":[0.9997048,0.00007552891,0.0000386409,0.00005887551,0.00004711995,0.00007508714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00203364,0.0002845415,0.003972622,0.001638108,0.0002434622,0.006978118,0.0006622734,0.0006898757,0.2794943,0.02658201,0.2019836,0.4754375],"study_design_scores_gemma":[0.0002835713,0.0004778027,0.005460246,0.0005813086,0.0002829041,0.01323127,0.0003339283,0.001164443,0.1069315,0.01825689,0.8529416,0.00005463475],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2410968,0.3851832,0.04839019,0.1232949,0.03271095,0.0003420678,0.003706217,0.004326485,0.1609492],"genre_scores_gemma":[0.6789518,0.1509477,0.01579239,0.06248039,0.011488,0.0003281357,0.003344836,0.0009195362,0.07574718],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004553818,"threshold_uncertainty_score":0.01523405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688166843168011,"score_gpt":0.2888935943532751,"score_spread":0.272011925921595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}