{"id":"W2605345821","doi":"10.1200/jco.2004.22.90140.4","title":"A multicenter phase III comparison of docetaxel (D) + prednisone (P) and mitoxantrone (MTZ) + P in patients with hormone-refractory prostate cancer (HRPC)","year":2004,"lang":"fr","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Mitoxantrone; Docetaxel; Neutropenia; Clinical endpoint; Internal medicine; Prednisone; Phases of clinical research; Gastroenterology; Toxicity; Prostate cancer; Bone pain; Estramustine; Refractory (planetary science); Urology; Surgery; Chemotherapy; Oncology; Cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001748814,0.0002996069,0.002685815,0.0002627669,0.00005087125,0.00001422712,0.0001770383,0.0005038201,0.0001073367],"category_scores_gemma":[0.0006834572,0.0001975287,0.0002465544,0.000259488,0.00116367,0.0003373986,0.00009089465,0.001837624,0.000006068067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008785998,"about_ca_system_score_gemma":0.003425797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004646865,"about_ca_topic_score_gemma":0.0004081551,"domain_scores_codex":[0.994374,0.0004918301,0.003395429,0.0003402553,0.0007362452,0.0006622602],"domain_scores_gemma":[0.9946048,0.0009507442,0.002676722,0.0002098388,0.0008483162,0.0007095663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1475317,0.03643416,0.5122296,0.0002598994,0.001188825,0.0005454897,0.001784421,0.000124184,0.0002489141,0.00001518333,0.000773131,0.2988645],"study_design_scores_gemma":[0.2916238,0.09619749,0.5905227,0.001865522,0.0009937281,0.00001856546,0.0006352194,0.000155798,0.0002250815,0.0000520211,0.0175238,0.0001862942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9014884,0.0892721,0.00003042196,0.006556692,0.001471695,0.0009690404,0.00007144163,0.000003801899,0.0001364453],"genre_scores_gemma":[0.9635255,0.03365205,0.001138524,0.0002390345,0.000764766,0.00001734118,0.00001205696,0.0000324241,0.0006182585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2986782,"threshold_uncertainty_score":0.8054987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08013408898120648,"score_gpt":0.4882761833763798,"score_spread":0.4081420943951733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}