{"id":"W2605345821","doi":"10.1200/jco.2004.22.90140.4","title":"A multicenter phase III comparison of docetaxel (D) + prednisone (P) and mitoxantrone (MTZ) + P in patients with hormone-refractory prostate cancer (HRPC)","year":2004,"lang":"fr","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Mitoxantrone; Docetaxel; Neutropenia; Clinical endpoint; Internal medicine; Prednisone; Phases of clinical research; Gastroenterology; Toxicity; Prostate cancer; Bone pain; Estramustine; Refractory (planetary science); Urology; Surgery; Chemotherapy; Oncology; Cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001943704,0.001240158,0.00143997,0.0004327874,0.000423686,0.0007925259,0.001013166,0.0009664844,0.004125028],"category_scores_gemma":[0.001282664,0.0006537339,0.001464303,0.000453858,0.0009414021,0.0007051656,0.0003732303,0.002304475,0.0006874963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009934822,"about_ca_system_score_gemma":0.001668019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101771,"about_ca_topic_score_gemma":0.002722216,"domain_scores_codex":[0.9993782,0.0003866369,0.00003389131,0.00008681124,0.00003965565,0.00007476134],"domain_scores_gemma":[0.9991012,0.0002007156,0.0002059709,0.00005948724,0.00004391881,0.0003887349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9280242,0.02440727,0.002031728,0.0004115508,0.0008382919,0.00005045675,0.00009565043,0.0009885904,0.00872971,0.000112433,0.001189172,0.03312092],"study_design_scores_gemma":[0.7011005,0.292126,0.003955847,0.00002164348,0.0004286691,0.0000721036,0.00002562688,0.0005092394,0.0008607146,0.00009073292,0.0007959553,0.00001297197],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918848,0.002616391,0.0005225778,0.0003766538,0.0001789031,0.002575823,0.0006059523,0.00005935129,0.001179631],"genre_scores_gemma":[0.9916571,0.001658612,0.00148986,0.0004784726,0.0002074704,0.002300805,0.0008796304,0.00002080637,0.001307179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004125028,"threshold_uncertainty_score":0.01379961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08013408898120648,"score_gpt":0.4882761833763798,"score_spread":0.4081420943951733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}