{"id":"W2605364700","doi":"10.1158/1557-3125.dnarepair16-a24","title":"Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synthetic lethality; Ribosome biogenesis; Cancer research; Biology; Homologous recombination; Cancer; Ovarian cancer; RNA interference; DNA repair; Gene; Genetics; Ribosome; RNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198774,0.0001815247,0.0002394806,0.0001622169,0.0003632251,0.0001077909,0.0007415052,0.0001772245,0.0001190334],"category_scores_gemma":[0.0002550407,0.0001684973,0.0001130031,0.0002280912,0.0005578275,0.00002263194,0.0002256288,0.0003186657,0.00000540112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168144,"about_ca_system_score_gemma":0.0005922419,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01262854,"about_ca_topic_score_gemma":0.005402118,"domain_scores_codex":[0.9977003,0.0002011542,0.0003452919,0.0006831862,0.0005603355,0.0005097083],"domain_scores_gemma":[0.9977447,0.00002449092,0.0002235555,0.001373069,0.0005361491,0.00009806354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002739817,0.0002455559,0.03647409,0.0001651223,0.0001093965,0.00006445384,0.0001619898,0.000727718,0.9561273,0.0003335006,0.0003352507,0.004981623],"study_design_scores_gemma":[0.0009899588,0.0002424616,0.6088983,0.0001849846,0.00002694921,0.000007045895,0.0001605447,0.0000494158,0.386499,0.0004842369,0.002132675,0.0003243762],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882494,0.006113161,0.0005036208,0.001034485,0.00008135547,0.0005362584,0.00006965628,0.00001102701,0.00340106],"genre_scores_gemma":[0.9967375,0.001688547,0.0001725724,0.00004699313,0.00004833491,0.0004638176,0.00003683584,0.00003742166,0.0007679972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5724243,"threshold_uncertainty_score":0.9939464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04608922935932508,"score_gpt":0.366154506654217,"score_spread":0.3200652772948919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}