{"id":"W2605372253","doi":"10.1038/leu.2017.108","title":"A novel AHI-1–BCR-ABL–DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Institutes of Health Research; Deutsche Krebshilfe; University of British Columbia","keywords":"Ponatinib; Autophagy; Cancer research; Stem cell; Biology; Cell biology; Endocytosis; Myeloid leukemia; Tyrosine kinase; Dasatinib; Progenitor cell; Imatinib mesylate; Immunology; Signal transduction; Cell; Apoptosis; Imatinib; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125623,0.0002605422,0.000231671,0.0001902455,0.0002175695,0.0002370833,0.0001806496,0.0002079515,0.0007271788],"category_scores_gemma":[0.00005835205,0.0001116182,0.0001632706,0.000113523,0.0001818084,0.0001827147,0.0002052216,0.0004170052,0.0001789933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005826723,"about_ca_system_score_gemma":0.0002048098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002619484,"about_ca_topic_score_gemma":0.000601963,"domain_scores_codex":[0.9999205,0.000009219813,0.000006708484,0.00002335746,0.00002537574,0.00001483108],"domain_scores_gemma":[0.999974,0.000002185379,0.000006820409,0.000002560221,0.000002771912,0.0000116528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006126933,0.00001620334,0.0001064123,0.00001945089,0.000004817014,0.00003350773,0.000005720957,0.00004290325,0.9989158,0.000146943,0.00004192303,0.0006050544],"study_design_scores_gemma":[0.00004696344,0.0001518089,0.003180126,0.000003629467,0.00002068019,0.0003931089,0.00001340417,0.001669602,0.9896792,0.00007361084,0.004762474,0.000005439301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991936,0.00206796,0.004105381,0.0002039575,0.000035675,0.00005061869,0.0002709972,0.0000803281,0.001248995],"genre_scores_gemma":[0.9952638,0.0005130279,0.00217175,0.00005301091,0.000008180333,0.00003102922,0.000415716,0.00001174447,0.001531681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007271788,"threshold_uncertainty_score":0.004227579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0414186278086687,"score_gpt":0.2650314953372631,"score_spread":0.2236128675285944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}