{"id":"W2605424074","doi":"10.1002/9781118647110.ch12","title":"Insulin Signaling Pathways in Humans and Plants","year":2017,"lang":"en","type":"other","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Agriculture and Agri-Food Canada","funders":"","keywords":"PTEN; Tensin; PI3K/AKT/mTOR pathway; Protein kinase B; Signal transduction; Biology; Insulin receptor; Cell biology; Kinase; Phosphoinositide 3-kinase; Insulin; Insulin resistance; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158413,0.0002698551,0.000182456,0.000459072,0.0003396455,0.0009026677,0.0001809021,0.0003319789,0.009584063],"category_scores_gemma":[0.000139921,0.0000710341,0.0001618677,0.0006411163,0.0003747058,0.0004009411,0.0005972295,0.0004957585,0.003170503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004172112,"about_ca_system_score_gemma":0.000308411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113419,"about_ca_topic_score_gemma":0.0009210154,"domain_scores_codex":[0.9999243,0.00001066307,0.000003994454,0.00002419071,0.0000228429,0.00001389316],"domain_scores_gemma":[0.9999579,0.000003631361,0.000009045722,0.000006106416,0.000008811371,0.00001441029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003368563,0.0001007263,0.004648668,0.0008184294,0.00005942539,0.001695329,0.0004199069,0.000337225,0.03522592,0.08118787,0.06311587,0.8120539],"study_design_scores_gemma":[0.0000205805,0.00005408306,0.01018953,0.0001996566,0.00002403554,0.00294507,0.0001906312,0.0001097334,0.003892939,0.0161918,0.9661673,0.00001472568],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.06052933,0.3170359,0.01945587,0.008987685,0.001170958,0.00009851809,0.003985847,0.001482115,0.5872538],"genre_scores_gemma":[0.4634561,0.2756557,0.01736206,0.00494285,0.0008114181,0.0001922937,0.004910951,0.0002537399,0.2324148],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.009584063,"threshold_uncertainty_score":0.03206193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081661991894597,"score_gpt":0.2641010909622741,"score_spread":0.2432844710433281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}