{"id":"W2605478904","doi":"10.1016/j.bmc.2017.04.013","title":"Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"King Saud University; Institute of Population and Public Health; University Grants Commission; Council of Scientific and Industrial Research, India","keywords":"Chemistry; HeLa; Thiazole; Tubulin; Molecular biology; Cell cycle; Annexin; Apoptosis; MTT assay; In vitro; Biochemistry; Microtubule; Stereochemistry; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001928945,0.0003762059,0.0003557759,0.0003311602,0.0002896387,0.0004603415,0.0005736882,0.0003984396,0.001985732],"category_scores_gemma":[0.0001777336,0.0003208472,0.0002037562,0.0004252278,0.0001803431,0.0002459972,0.0001980777,0.0004512149,0.0007150045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007973603,"about_ca_system_score_gemma":0.0004873354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000838427,"about_ca_topic_score_gemma":0.002487962,"domain_scores_codex":[0.9998991,0.00001819156,0.000009211944,0.0000177456,0.00002119625,0.00003449069],"domain_scores_gemma":[0.9999348,0.000005936709,0.00002321934,0.000004676199,0.00001391691,0.00001735758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002406442,0.0001598639,0.0002138614,0.0002384732,0.00002601725,0.0002534977,0.0001061876,0.002620051,0.9793457,0.002314114,0.0006477479,0.01383388],"study_design_scores_gemma":[0.0001849932,0.001256592,0.001078738,0.00001965757,0.00006909271,0.0002283316,0.00002741329,0.004796244,0.9726628,0.0001563383,0.01949294,0.00002691196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9221371,0.01053688,0.04291719,0.0008145319,0.0002495632,0.0008934415,0.001183596,0.0007774237,0.0204903],"genre_scores_gemma":[0.9674414,0.004948596,0.01695643,0.0001397976,0.00003461764,0.0003105463,0.0006834238,0.00005063514,0.009434572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985732,"threshold_uncertainty_score":0.006642938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026356253443833,"score_gpt":0.2441966011318061,"score_spread":0.2239330385973677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}