{"id":"W2605478904","doi":"10.1016/j.bmc.2017.04.013","title":"Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"King Saud University; Institute of Population and Public Health; University Grants Commission; Council of Scientific and Industrial Research, India","keywords":"Chemistry; HeLa; Thiazole; Tubulin; Molecular biology; Cell cycle; Annexin; Apoptosis; MTT assay; In vitro; Biochemistry; Microtubule; Stereochemistry; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004341594,0.0003466936,0.0005941616,0.00002407179,0.0003436064,0.00007005852,0.0005337885,0.0005212973,0.00185364],"category_scores_gemma":[0.003097663,0.0002732206,0.0001041522,0.00006574841,0.0006513256,0.000115804,0.0002063348,0.0002978811,0.00001714037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005246694,"about_ca_system_score_gemma":0.000127102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001466432,"about_ca_topic_score_gemma":0.000001060703,"domain_scores_codex":[0.9981696,0.00004099616,0.0005078723,0.0005538522,0.0003694081,0.0003582762],"domain_scores_gemma":[0.997675,0.0006907342,0.0006228703,0.0006762169,0.00009487337,0.0002402907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806691,0.0001744184,0.003930726,0.0002496326,0.0000792686,0.0000154079,0.00005510246,3.829974e-7,0.983932,0.00001013887,0.00008970076,0.01128254],"study_design_scores_gemma":[0.0006065561,0.00004259508,0.002396439,0.00032186,0.0001361697,0.00004612804,0.0002562247,0.0001240452,0.9953446,0.0001300431,0.0002882666,0.0003070171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937447,0.0008286966,0.00006672937,0.0009910442,0.00008657859,0.0001005766,0.00002592289,0.00008903974,0.004066676],"genre_scores_gemma":[0.9985434,0.0003963949,0.000190808,0.00005047296,0.0005383192,0.00001924974,0.00001550225,0.00003248559,0.00021339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01141264,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026356253443833,"score_gpt":0.2441966011318061,"score_spread":0.2239330385973677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}