{"id":"W2605513847","doi":"10.3390/cancers9040034","title":"AR Signaling and the PI3K Pathway in Prostate Cancer","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Prostate cancer; Androgen receptor; PI3K/AKT/mTOR pathway; Androgen; Medicine; Signal transduction; Cancer research; Mechanism (biology); Cancer; Prostate; Disease; Bioinformatics; Internal medicine; Biology; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003643319,0.0006362261,0.0007756655,0.002113366,0.0003193552,0.0009961809,0.0005867936,0.000759245,0.005203507],"category_scores_gemma":[0.0005322088,0.0001894533,0.0005306471,0.002067799,0.0002775235,0.001038407,0.0006264956,0.001697896,0.002429149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006091592,"about_ca_system_score_gemma":0.001240092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266581,"about_ca_topic_score_gemma":0.002588323,"domain_scores_codex":[0.9998574,0.0000196625,0.00002235865,0.00002411122,0.00005758526,0.00001880694],"domain_scores_gemma":[0.9998342,0.00005477912,0.00002566285,0.000004890359,0.00006185087,0.00001861345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008599924,0.0000657101,0.000301254,0.01587739,0.0000946944,0.0002365996,0.00006876928,0.0003113426,0.001667933,0.004394884,0.03920206,0.9376934],"study_design_scores_gemma":[0.000009399306,0.00006632948,0.0007687687,0.002782707,0.00008827638,0.001090896,0.00004809827,0.00006917649,0.0003437161,0.001718319,0.9930001,0.00001426013],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001434876,0.997681,0.0001097512,0.0004112819,0.0002072409,0.000005320784,0.00003839234,0.00001147303,0.001391868],"genre_scores_gemma":[0.0007319229,0.9981182,0.0001296067,0.0001927954,0.000128745,0.00000467168,0.00004551007,0.000001315217,0.0006473642],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005203507,"threshold_uncertainty_score":0.01740748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312354213497273,"score_gpt":0.4282921684734695,"score_spread":0.2970567471237421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}