{"id":"W2605587330","doi":"10.1038/oncsis.2017.22","title":"Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma","year":2017,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Newfoundland and Labrador Centre for Applied Health Research; Health Sciences Centre; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Woodchuck hepatitis virus; Hepatitis B virus; Biology; Virology; Virus; Hepadnaviridae; Hepatocellular carcinoma; Hepatitis B virus PRE beta; cccDNA; Hepatitis B virus DNA polymerase; Genetics; HBsAg","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151232,0.0001440321,0.000152298,0.0002304659,0.0001547753,0.0002107777,0.00008439387,0.000205221,0.001180342],"category_scores_gemma":[0.00007597457,0.0001503111,0.0001385551,0.0001191928,0.0001480659,0.0001692436,0.0001567694,0.0003102444,0.0004382555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900098,"about_ca_system_score_gemma":0.0001114354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001662555,"about_ca_topic_score_gemma":0.001854147,"domain_scores_codex":[0.9999052,0.00002571375,0.000006184874,0.00002049271,0.00001754419,0.0000248331],"domain_scores_gemma":[0.9999417,0.00001230242,0.000008969536,0.000009990574,0.000007279979,0.00001975361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004749194,0.0001008458,0.001243812,0.00002166733,0.000004566989,0.0001396607,0.00006349087,0.00008124278,0.9966642,0.0000738665,0.00002222978,0.00110951],"study_design_scores_gemma":[0.00002410465,0.002618792,0.02653805,0.000006378823,0.00002132531,0.0005073298,0.0002139113,0.001493074,0.9671441,0.00009157827,0.001328795,0.00001249978],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971915,0.0008212586,0.0008003027,0.00001392144,0.000008989163,0.0000221722,0.0001382161,0.00003130216,0.0009722607],"genre_scores_gemma":[0.9963459,0.0004183654,0.0006125557,0.00001365777,0.000003238539,0.00002560304,0.0002950063,0.000009402347,0.002276272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662555,"threshold_uncertainty_score":0.003948689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06023920818438119,"score_gpt":0.3180862397622142,"score_spread":0.2578470315778331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}