{"id":"W2605641231","doi":"10.1016/j.nano.2017.04.010","title":"Enhancing targeted antibiotic therapy via pH responsive solid lipid nanoparticles from an acid cleavable lipid","year":2017,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"","keywords":"Solid lipid nanoparticle; In vivo; Staphylococcus aureus; Chemistry; Dispersity; Zeta potential; Antibiotics; In vitro; Antibacterial activity; Particle size; Vancomycin; Microbiology; Chromatography; Bacteria; Nanoparticle; Biochemistry; Nanotechnology; Biology; Materials science; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112705,0.0002542948,0.0001097794,0.000106743,0.00007513184,0.000188459,0.0001162659,0.0003362587,0.0007891298],"category_scores_gemma":[0.0001062029,0.000121208,0.0001698559,0.00006132395,0.0001489566,0.0002627368,0.0002396958,0.0002963903,0.0003311785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317366,"about_ca_system_score_gemma":0.0001509455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002375322,"about_ca_topic_score_gemma":0.0002691277,"domain_scores_codex":[0.9999409,0.000008358399,0.00000435219,0.0000136448,0.00001850544,0.00001420295],"domain_scores_gemma":[0.9999506,0.00001015203,0.00002095003,0.000003414513,0.000007842681,0.000006934448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003054225,0.000004732992,0.00001940125,0.00001810533,0.000001407077,0.00003072068,0.000006362926,0.0001003816,0.9986724,0.0001126999,0.00001967826,0.0009835307],"study_design_scores_gemma":[0.00000527721,0.00004942777,0.0001066084,0.000001288088,0.000003122579,0.00004308212,0.000002424947,0.0006015988,0.9983725,0.00001923964,0.0007937144,0.000001874485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971517,0.001549237,0.02170995,0.0002883202,0.00005984587,0.00006763291,0.0001250527,0.0001733757,0.004509624],"genre_scores_gemma":[0.9894422,0.0006395508,0.006383881,0.00008540593,0.00001160981,0.00002664947,0.00005882119,0.00002260797,0.003329285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007891298,"threshold_uncertainty_score":0.002639949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05944571674784436,"score_gpt":0.429833548515051,"score_spread":0.3703878317672066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}