{"id":"W2605682952","doi":"10.21083/surg.v9i1.3800","title":"Mitochondrial replacement therapy and the “three parent baby”","year":2017,"lang":"en","type":"article","venue":"SURG Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Zygote; Mitochondrial DNA; Pronucleus; Polar body; Oocyte; Biology; Genetics; Mitochondrion; Germline; Mutation; Cell biology; Embryo; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004895358,0.0001043966,0.0001283772,0.00001733242,0.00069178,0.000178956,0.0002316132,0.00008653393,0.0001624862],"category_scores_gemma":[0.0001682059,0.00006225634,0.0001051503,0.000009074354,0.0002217628,0.000004560851,0.00009173337,0.0001625211,0.00000917754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005689417,"about_ca_system_score_gemma":0.00005747583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000015511,"about_ca_topic_score_gemma":0.00007133378,"domain_scores_codex":[0.9992086,0.0001280734,0.000180878,0.0001780667,0.0001173958,0.0001869926],"domain_scores_gemma":[0.9991791,0.00001846785,0.0001921487,0.0004564767,0.00006213348,0.00009166326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03234497,0.0002305494,0.1117069,0.00001397448,0.0007889688,0.0001025684,0.0005083216,0.00003249183,0.4469064,0.003242387,0.2218639,0.1822586],"study_design_scores_gemma":[0.01186537,0.000548987,0.01011441,0.0000121615,0.00002425936,0.0006535304,0.0000563797,0.00002488591,0.01248443,0.0014598,0.9625502,0.0002056211],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753334,0.003341783,0.004407967,0.003928056,0.007290436,0.0003229883,0.00000696151,0.000007183174,0.005361236],"genre_scores_gemma":[0.9767717,0.007819933,0.001085393,0.001446914,0.009057556,0.0000350557,0.0000179845,0.000031494,0.00373395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7406862,"threshold_uncertainty_score":0.5320683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091246592963419,"score_gpt":0.2775805359007815,"score_spread":0.2466680699711473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}