{"id":"W2605682952","doi":"10.21083/surg.v9i1.3800","title":"Mitochondrial replacement therapy and the “three parent baby”","year":2017,"lang":"en","type":"article","venue":"SURG Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Zygote; Mitochondrial DNA; Pronucleus; Polar body; Oocyte; Biology; Genetics; Mitochondrion; Germline; Mutation; Cell biology; Embryo; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001414209,0.0003215107,0.0002768528,0.000353725,0.0006722314,0.0005887204,0.0004860439,0.001998207,0.004228205],"category_scores_gemma":[0.001539156,0.0001142093,0.0003896729,0.0002596232,0.003220696,0.001242739,0.001322086,0.002879101,0.001152963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007184093,"about_ca_system_score_gemma":0.001051984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006523262,"about_ca_topic_score_gemma":0.001047354,"domain_scores_codex":[0.9994069,0.0002670353,0.00003680341,0.00008653913,0.0001538721,0.00004871987],"domain_scores_gemma":[0.9996707,0.0001302517,0.00006034056,0.00004800512,0.00003429652,0.00005641689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003619152,0.000182209,0.001406371,0.0005712558,0.00005480558,0.00424244,0.000841002,0.0003764953,0.007039012,0.5017976,0.07774064,0.4053863],"study_design_scores_gemma":[0.0001050629,0.000706437,0.001313041,0.0004634043,0.00005352117,0.02634505,0.0003153732,0.000552193,0.004983791,0.09553361,0.8695692,0.00005927051],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05955,0.3469453,0.1670728,0.2357651,0.0255476,0.0003043249,0.0004212551,0.001102723,0.1632911],"genre_scores_gemma":[0.4715352,0.2067997,0.09703537,0.09591961,0.006362064,0.0006214865,0.0004748608,0.0002837869,0.1209679],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004228205,"threshold_uncertainty_score":0.01414478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091246592963419,"score_gpt":0.2775805359007815,"score_spread":0.2466680699711473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}