{"id":"W2605687312","doi":"10.1152/ajpheart.00800.2016","title":"Toll-like receptor 2 dominance over Toll-like receptor 4 in stressful conditions for its detrimental role in the heart","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"TLR4; Receptor; TLR2; Toll-like receptor; Downregulation and upregulation; Tumor necrosis factor alpha; Signal transduction; Biology; Cell biology; Apoptosis; Knockout mouse; Endocrinology; Immunology; Innate immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815282,0.0005177479,0.0002388797,0.0002225067,0.0001675182,0.0003280268,0.0001255774,0.0003115088,0.00174084],"category_scores_gemma":[0.0001332489,0.0001318028,0.0003099606,0.0000793168,0.0002475813,0.0002451534,0.000254509,0.0005990994,0.0002486084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226787,"about_ca_system_score_gemma":0.0001438247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008341415,"about_ca_topic_score_gemma":0.0001474832,"domain_scores_codex":[0.9998474,0.00003887908,0.00001293759,0.0000290986,0.00002369836,0.00004785927],"domain_scores_gemma":[0.9998852,0.00001250404,0.00003633198,0.000009508319,0.00001279262,0.0000436585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004087224,0.00002125176,0.001086956,0.0001080061,0.000007752143,0.000228725,0.00002321941,0.00003349314,0.9961534,0.0001223953,0.00003948677,0.001766606],"study_design_scores_gemma":[0.0001246007,0.003340496,0.1079244,0.0000925094,0.0001875921,0.004132119,0.0004548557,0.001256597,0.8728297,0.001152465,0.008463696,0.00004094749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856893,0.008937472,0.002906181,0.0003292867,0.0001544229,0.00002424048,0.0001268987,0.0000445007,0.00178769],"genre_scores_gemma":[0.9941306,0.002686903,0.001279076,0.0001854484,0.00009049501,0.00003383297,0.000118807,0.000008077094,0.00146664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00174084,"threshold_uncertainty_score":0.005823672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009893668860105733,"score_gpt":0.2644391042166698,"score_spread":0.2545454353565641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}