{"id":"W2605735623","doi":"10.1021/acsmedchemlett.6b00504","title":"Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic","year":2017,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Ionic liquids properties and applications","field":"Chemical Engineering","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canada Excellence Research Chairs, Government of Canada; Howard Hughes Medical Institute","keywords":"Transdermal; Lidocaine; Bioavailability; Absorption (acoustics); Chemistry; Eutectic system; Chromatography; Salt (chemistry); Pharmacology; Organic chemistry; Materials science; Anesthesia; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003561378,0.0007307339,0.0004997348,0.0004825334,0.0002287334,0.0003352149,0.0002421365,0.0004293368,0.001829867],"category_scores_gemma":[0.0003006396,0.0003471528,0.0005343314,0.0002595824,0.0005338925,0.0006726919,0.0001861613,0.001256184,0.0004799103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003952785,"about_ca_system_score_gemma":0.0005142532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029772,"about_ca_topic_score_gemma":0.001336647,"domain_scores_codex":[0.9997073,0.00004471572,0.00001836908,0.00008259094,0.00004952506,0.00009742364],"domain_scores_gemma":[0.9995887,0.00006427465,0.0001445259,0.00005941124,0.00006218702,0.00008096304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005371645,0.0007356,0.0003155402,0.00006922542,0.00002260099,0.00006090919,0.00006040061,0.0001661788,0.9871164,0.00015044,0.0001322515,0.005798728],"study_design_scores_gemma":[0.0001731523,0.01332376,0.001549793,0.000007750547,0.00008139512,0.00008143488,0.00006901211,0.0007007761,0.9823616,0.00006732369,0.001568363,0.00001550273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932746,0.0009521113,0.003157274,0.0001529965,0.00009218828,0.0001097574,0.0006436961,0.0001435122,0.001473859],"genre_scores_gemma":[0.9852331,0.002048894,0.004563607,0.00014715,0.00005731941,0.0002611062,0.0005306187,0.00007006805,0.007088054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829867,"threshold_uncertainty_score":0.006121516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189222909298754,"score_gpt":0.2420682788687517,"score_spread":0.2301760497757641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}