{"id":"W2605743022","doi":"10.1002/pbc.26414","title":"A phase 1 study of the CXCR4 antagonist plerixafor in combination with high‐dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators’ Consortium study (POE 10‐03)","year":2017,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"Hyundai Hope On Wheels; St. Baldrick's Foundation; American Cancer Society; Leukemia and Lymphoma Society; National Cancer Institute; Conquer Cancer Foundation; National Institutes of Health","keywords":"Plerixafor; Medicine; Cytarabine; Etoposide; Internal medicine; Chemotherapy; Oncology; Refractory (planetary science); Gastroenterology; CXCR4","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003355035,0.0004137724,0.0009377839,0.0003291977,0.0002572068,0.00005276203,0.0002926819,0.0001584534,0.00009554807],"category_scores_gemma":[0.00008792566,0.0002376876,0.000043097,0.0006882002,0.0002361915,0.0001908498,0.000152083,0.0005851364,9.56703e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706244,"about_ca_system_score_gemma":0.001852522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00227587,"about_ca_topic_score_gemma":0.002184008,"domain_scores_codex":[0.9975303,0.0001826451,0.0007148213,0.0006160602,0.0005553431,0.0004008169],"domain_scores_gemma":[0.9981519,0.0001861744,0.0007829528,0.0005813593,0.0001249248,0.0001727141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006427212,0.01527121,0.9726908,0.00009512431,0.0005022801,0.0003924962,0.003505433,0.00001575716,0.0008683169,0.000001449369,0.00003968279,0.0001902135],"study_design_scores_gemma":[0.1232587,0.04314556,0.8228928,0.0001033575,0.005077033,0.000454745,0.002267185,0.00009031877,0.002230749,0.000002689537,0.00001781519,0.0004590084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955975,0.0008130153,9.570407e-7,0.0001717338,0.0001572407,0.003181923,0.00003573871,0.00002856272,0.00001336986],"genre_scores_gemma":[0.9983681,0.000545446,0.00008399423,0.00009359325,0.0002363599,0.0004405512,0.0000138304,0.00006534332,0.0001527277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1497979,"threshold_uncertainty_score":0.9692619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515996934754412,"score_gpt":0.3226069318202358,"score_spread":0.2974469624726916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}