{"id":"W2605822943","doi":"10.1200/jco.2012.30.15_suppl.tps8604","title":"OPTiM: A randomized phase III trial to evaluate the efficacy and safety of talimogene laherparepvec (T-VEC) compared with subcutaneously (sc) administered GM-CSF for the treatment (tx) of unresectable stage IIIb, IIIc, and IV melanoma.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Oncolytic virus; Clinical endpoint; Internal medicine; Melanoma; Stage (stratigraphy); Randomized controlled trial; Clinical trial; Phases of clinical research; Oncology; Immune system; Gastroenterology; Urology; Surgery; Immunology; Cancer; Cancer research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002273519,0.001876711,0.002216724,0.0005007846,0.0003580726,0.001009435,0.0009667723,0.001618577,0.01013192],"category_scores_gemma":[0.001653833,0.0007219906,0.001497287,0.0003691456,0.001375198,0.001172757,0.0005259577,0.003122574,0.001555522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009796838,"about_ca_system_score_gemma":0.0009732126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007172508,"about_ca_topic_score_gemma":0.001410809,"domain_scores_codex":[0.9994339,0.0003163211,0.00001988733,0.0001011549,0.00004515368,0.00008353432],"domain_scores_gemma":[0.9989473,0.0002754738,0.0002894756,0.00008654637,0.00004580943,0.0003553609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9833576,0.005026464,0.0006761537,0.0002030764,0.0003312596,0.00002747717,0.00002913293,0.0003489747,0.002515392,0.0001072858,0.00083602,0.006541059],"study_design_scores_gemma":[0.9064097,0.08983486,0.001622709,0.00002046319,0.000289068,0.00005369433,0.00001636219,0.0005001301,0.0004284803,0.0001914376,0.0006219567,0.00001120396],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821592,0.002972298,0.000945796,0.001021071,0.0004685198,0.006187126,0.002738262,0.0001959305,0.003311784],"genre_scores_gemma":[0.9755023,0.001866073,0.002770137,0.0018682,0.0005628121,0.008593065,0.003366341,0.00006068652,0.005410398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01013192,"threshold_uncertainty_score":0.03389466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1822183919849854,"score_gpt":0.5002039924997621,"score_spread":0.3179856005147767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}