{"id":"W2605860823","doi":"10.1016/j.chom.2017.03.008","title":"Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape","year":2017,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":381,"is_retracted":false,"has_abstract":false,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto","funders":"National Institutes of Health; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; Gilead Sciences; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, Johns Hopkins University; Delaney AIDS Research Enterprise; Bill and Melinda Gates Foundation; W. W. Smith Charitable Trust; Howard Hughes Medical Institute","keywords":"Biology; Cytotoxic T cell; Virology; CTL*; Epitope; Immunology; Genetics; Antigen; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665391,0.0005589611,0.0004131715,0.0004821091,0.0003691314,0.001978546,0.00031284,0.000674258,0.003173245],"category_scores_gemma":[0.0005195101,0.0003596981,0.0004374131,0.0002196014,0.0006108205,0.0008828167,0.0006719822,0.00183775,0.001820355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000794886,"about_ca_system_score_gemma":0.0002215323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143252,"about_ca_topic_score_gemma":0.0003504328,"domain_scores_codex":[0.9995263,0.00005712768,0.00001858998,0.000100844,0.0001539831,0.0001432885],"domain_scores_gemma":[0.999782,0.00004323875,0.00004765398,0.00004104536,0.00003890013,0.00004717458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316246,0.0000306655,0.001516453,0.00007188008,0.0000173901,0.0001714375,0.00009219116,0.0002852654,0.9873405,0.002399104,0.0003229098,0.007620551],"study_design_scores_gemma":[0.00006721049,0.0003265444,0.01371552,0.00005917406,0.00005835452,0.001950765,0.0004370995,0.002996329,0.9602097,0.00378072,0.01636332,0.00003521428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701292,0.008789707,0.01129256,0.0004384339,0.0002376802,0.00005420373,0.0004243142,0.0002197515,0.008414131],"genre_scores_gemma":[0.9911674,0.001203597,0.002738345,0.00017443,0.00004871738,0.00002124707,0.000483564,0.00006886652,0.00409402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173245,"threshold_uncertainty_score":0.01061553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438861376177691,"score_gpt":0.2408391648171034,"score_spread":0.2264505510553265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}