{"id":"W2605860823","doi":"10.1016/j.chom.2017.03.008","title":"Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape","year":2017,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":381,"is_retracted":false,"has_abstract":false,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto","funders":"National Institutes of Health; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; Gilead Sciences; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, Johns Hopkins University; Delaney AIDS Research Enterprise; Bill and Melinda Gates Foundation; W. W. Smith Charitable Trust; Howard Hughes Medical Institute","keywords":"Biology; Cytotoxic T cell; Virology; CTL*; Epitope; Immunology; Genetics; Antigen; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0002114108,0.0003265013,0.0003624966,0.00005846468,0.001336872,0.0002093368,0.0005555762,0.0002460525,0.000453306],"category_scores_gemma":[0.0001702984,0.0002190066,0.00008747177,0.0000658815,0.0004667006,0.0001362605,0.0003581322,0.0003470049,0.0007311841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008389293,"about_ca_system_score_gemma":0.0002296154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005921029,"about_ca_topic_score_gemma":0.000819614,"domain_scores_codex":[0.9982266,0.0002597137,0.0002133136,0.0005785,0.00005511067,0.0006667321],"domain_scores_gemma":[0.9986169,0.0001916499,0.0002404211,0.000744418,0.0001291074,0.0000774507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004144512,0.0003215465,0.02165249,0.00004616852,0.000200806,0.00002295219,0.0007640116,9.362083e-8,0.9153318,0.000003368312,0.05912191,0.002120411],"study_design_scores_gemma":[0.006544288,0.0003091715,0.01793018,0.00005971426,0.00009914827,0.00005214081,0.0006345981,0.000003359335,0.8725708,0.00001299408,0.1014362,0.0003474227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838918,0.008788854,0.000004141578,0.001343032,0.0001578431,0.001096994,0.00189405,0.00006680099,0.002756526],"genre_scores_gemma":[0.9906429,0.0006976687,0.0000280227,0.0002487657,0.0000360268,0.0002242277,0.000531392,0.00003856437,0.007552446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04276099,"threshold_uncertainty_score":0.9999632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438861376177691,"score_gpt":0.2408391648171034,"score_spread":0.2264505510553265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}