{"id":"W2605885227","doi":"10.1016/j.actbio.2017.04.024","title":"Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly(amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids","year":2017,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Major Science and Technology Projects of China; National Key Research and Development Program of China; Science and Technology Major Project of Guangxi; Shanghai Rising-Star Program; National Natural Science Foundation of China","keywords":"Small hairpin RNA; Transfection; Gene delivery; In vivo; Nanomedicine; Hyaluronic acid; Chemistry; Materials science; CD44; Biophysics; Molecular biology; In vitro; Nanoparticle; Biology; Biochemistry; Nanotechnology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003434699,0.0003786374,0.0004150704,0.00007270533,0.0004869284,0.0002067586,0.000969874,0.0002921167,0.00005130745],"category_scores_gemma":[0.0001551536,0.0003000139,0.0002633361,0.00006124828,0.0004280289,0.00004740418,0.0003995492,0.00007115974,0.00001439356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003577863,"about_ca_system_score_gemma":0.000120996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004431803,"about_ca_topic_score_gemma":0.0000842631,"domain_scores_codex":[0.9979556,0.00005787621,0.0005512413,0.0006437031,0.000221512,0.0005701301],"domain_scores_gemma":[0.9979784,0.00002790353,0.0003483205,0.001359024,0.0001683043,0.0001180812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001056219,0.00007929184,0.002229358,0.00006495292,0.0002670519,0.000007708242,0.00009682886,0.000004365951,0.9897115,0.00001670003,0.005394434,0.001071583],"study_design_scores_gemma":[0.001087849,0.0007011725,0.009752809,0.00007395372,0.0001252154,0.00001943779,0.0001542368,0.0009258629,0.985067,0.00004328232,0.00166992,0.0003792243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958683,0.0007089186,0.00004855656,0.0002500097,0.002141281,0.0004560281,0.0002834267,0.00003555188,0.0002079171],"genre_scores_gemma":[0.997586,0.0003492701,0.0003168957,0.0001304059,0.0005474057,0.00007293955,0.0002473222,0.00005487718,0.0006948881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007523451,"threshold_uncertainty_score":0.9999452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04071802473048344,"score_gpt":0.2821272182176803,"score_spread":0.2414091934871969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}