{"id":"W2605885227","doi":"10.1016/j.actbio.2017.04.024","title":"Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly(amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids","year":2017,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Major Science and Technology Projects of China; National Key Research and Development Program of China; Science and Technology Major Project of Guangxi; Shanghai Rising-Star Program; National Natural Science Foundation of China","keywords":"Small hairpin RNA; Transfection; Gene delivery; In vivo; Nanomedicine; Hyaluronic acid; Chemistry; Materials science; CD44; Biophysics; Molecular biology; In vitro; Nanoparticle; Biology; Biochemistry; Nanotechnology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152463,0.0002351921,0.0001483439,0.0001313931,0.00009407437,0.0002181287,0.0001810336,0.0002466024,0.000599427],"category_scores_gemma":[0.0001076671,0.000135177,0.0001637165,0.000109904,0.0001492404,0.0002392357,0.0002091695,0.0003219898,0.0002385124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830863,"about_ca_system_score_gemma":0.0001921657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003663244,"about_ca_topic_score_gemma":0.0005651865,"domain_scores_codex":[0.999909,0.00001464424,0.00000839003,0.00002179926,0.0000278994,0.00001829872],"domain_scores_gemma":[0.9999382,0.00001024048,0.00002071767,0.000005496015,0.00000959637,0.00001557689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000299261,0.000007684631,0.00002373727,0.00001937519,0.000002681897,0.00001456391,0.000006836208,0.00009130073,0.9986914,0.0001129235,0.00001341076,0.0009862219],"study_design_scores_gemma":[0.000004558128,0.00003965974,0.00017995,9.798707e-7,0.000006083016,0.00003745878,0.000002452153,0.000864076,0.9982686,0.00001152212,0.0005824633,0.000002255562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849935,0.001129356,0.01170443,0.00006085673,0.00003485977,0.00002924913,0.00007547489,0.00009662125,0.001875848],"genre_scores_gemma":[0.9929715,0.0003354815,0.004129627,0.00002914331,0.000006963447,0.00001860812,0.00006826655,0.0000165686,0.002423808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000599427,"threshold_uncertainty_score":0.002053976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04071802473048344,"score_gpt":0.2821272182176803,"score_spread":0.2414091934871969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}