{"id":"W2605899137","doi":"10.1021/acs.orglett.7b00291","title":"One-Step Transformation of Coenzyme A into Analogues by Transamidation","year":2017,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nonribosomal peptide; Chemistry; Polyketide; Coenzyme A; Acyl carrier protein; Combinatorial chemistry; Enzyme; Biochemistry; Cofactor; Stereochemistry; Catalysis; Biosynthesis; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007339368,0.00006752402,0.0001089011,0.0000143387,0.00008348805,0.00002367015,0.000179427,0.00006147869,0.00005599643],"category_scores_gemma":[0.0000283667,0.0000668287,0.00007825702,0.00002307518,0.00006315592,0.000008355902,0.00001287323,0.00003148157,0.000004777717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009742593,"about_ca_system_score_gemma":0.000007712376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009432379,"about_ca_topic_score_gemma":0.00006468804,"domain_scores_codex":[0.9995289,0.00001244568,0.0001480067,0.0001353289,0.00008830593,0.00008697285],"domain_scores_gemma":[0.9995871,0.000004060812,0.00009838992,0.0002594948,0.00002054487,0.00003039875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001148156,0.00002576706,0.0002097834,0.00001562293,0.00005067061,8.819157e-8,0.00006132385,5.382005e-7,0.993672,0.000008844867,0.00213534,0.003808552],"study_design_scores_gemma":[0.0002212451,0.00002173656,0.0006278492,0.00000842994,0.00004068828,3.333205e-7,0.00001948455,0.00003300855,0.9959717,0.00001161517,0.002961832,0.00008212052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646339,0.00007235963,0.03019989,0.004941967,0.00001722405,0.00004427932,0.00001583463,0.0000044855,0.00007003753],"genre_scores_gemma":[0.9989474,0.00008888466,0.000246687,0.0004597695,0.00005376275,0.000002708197,0.0001802756,0.000008495315,0.00001197399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03431352,"threshold_uncertainty_score":0.2725196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007126455313327238,"score_gpt":0.2192233870195896,"score_spread":0.2120969317062624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}