{"id":"W2605899137","doi":"10.1021/acs.orglett.7b00291","title":"One-Step Transformation of Coenzyme A into Analogues by Transamidation","year":2017,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nonribosomal peptide; Chemistry; Polyketide; Coenzyme A; Acyl carrier protein; Combinatorial chemistry; Enzyme; Biochemistry; Cofactor; Stereochemistry; Catalysis; Biosynthesis; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135118,0.0006107215,0.0003850427,0.0002081604,0.0001859513,0.0002751033,0.0003569036,0.0003190402,0.001427586],"category_scores_gemma":[0.000251354,0.0001903409,0.000319879,0.000247186,0.0002246964,0.0004354724,0.0003809916,0.0007109261,0.001132279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245933,"about_ca_system_score_gemma":0.0004061357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005540974,"about_ca_topic_score_gemma":0.0006534963,"domain_scores_codex":[0.9998362,0.00001975621,0.00001705989,0.00005793387,0.0000314442,0.00003753614],"domain_scores_gemma":[0.9999005,0.00001471591,0.00001958052,0.00002721625,0.00001881172,0.000019223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135089,0.00004452056,0.00008074343,0.00009655431,0.00001220456,0.0001233244,0.00004077613,0.000193571,0.9917889,0.0006141971,0.00007878776,0.006791302],"study_design_scores_gemma":[0.00001381009,0.0001929425,0.000155181,0.00000346271,0.000008622806,0.0002033897,0.00001022681,0.000285023,0.9953138,0.00009868863,0.003703843,0.00001105187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8520732,0.003387082,0.1281521,0.0002421183,0.0002745237,0.00041889,0.0008220939,0.0006778528,0.01395205],"genre_scores_gemma":[0.9611148,0.002113072,0.03055143,0.0000525735,0.00001494326,0.0000903833,0.0004857624,0.0001001095,0.005476945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427586,"threshold_uncertainty_score":0.004775763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007126455313327238,"score_gpt":0.2192233870195896,"score_spread":0.2120969317062624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}