{"id":"W2606139221","doi":"10.1111/cas.13255","title":"Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel histone deacetylase/ phosphatidylinositol 3‐kinase dual inhibitor","year":2017,"lang":"en","type":"article","venue":"Cancer Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Depsipeptide; Romidepsin; Histone deacetylase; In vivo; Pharmacology; Histone deacetylase inhibitor; Chemistry; Cancer research; Medicine; Biology; Biochemistry; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003722305,0.0001378699,0.0001478028,0.00005327311,0.0008308999,0.00008596156,0.0006014954,0.0000719578,0.00001420432],"category_scores_gemma":[0.0003470407,0.0001092032,0.00005287365,0.0001842727,0.001922978,0.00004962734,0.0005369802,0.0001331287,0.000002691593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009639283,"about_ca_system_score_gemma":0.0007258587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003149764,"about_ca_topic_score_gemma":0.0001091086,"domain_scores_codex":[0.9986501,0.00003517089,0.0001538993,0.0004851655,0.0003736622,0.0003020075],"domain_scores_gemma":[0.998767,0.000009186911,0.0002793155,0.0005914328,0.0002203637,0.0001327464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007155354,0.00007157464,0.002878385,0.0000213623,0.000007303947,0.000003236692,0.00005136661,0.000005138001,0.9941379,0.00002952157,0.0001049021,0.002617708],"study_design_scores_gemma":[0.0004746483,0.00009579201,0.1008666,0.00003348478,0.00001072478,0.00001348278,0.00000726394,0.0002173456,0.8973146,0.000002642841,0.0008429464,0.0001204194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980545,0.0002097321,0.00009916742,0.000454299,0.0005387748,0.0003089579,0.00006656838,0.000006897675,0.0002611263],"genre_scores_gemma":[0.9988812,0.0001653097,0.00007814304,0.0001221336,0.0001510792,0.00004382843,0.000004092275,0.00001056629,0.000543672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09798823,"threshold_uncertainty_score":0.7085292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901267719140571,"score_gpt":0.3463812021487718,"score_spread":0.3273685249573661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}