{"id":"W2606177303","doi":"10.1038/s41598-017-01088-6","title":"Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institutes of Health; National Research Foundation of Korea; National Research Foundation","keywords":"Habenula; Anhedonia; Cholinergic; Ventral tegmental area; Neuroscience; Interpeduncular nucleus; Dorsal raphe nucleus; Dopamine; Endocrinology; Internal medicine; Choline acetyltransferase; Biology; Medicine; Serotonin; Serotonergic; Dopaminergic; Receptor; Central nervous system; Midbrain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009609994,0.000286513,0.000216438,0.0002539321,0.0001732963,0.0002236212,0.0001755566,0.0002590095,0.001277024],"category_scores_gemma":[0.0000973343,0.0001598039,0.0002315504,0.0001081971,0.0003256658,0.000139785,0.0002040457,0.0006646154,0.0002378021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003197204,"about_ca_system_score_gemma":0.00024249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001196606,"about_ca_topic_score_gemma":0.004562955,"domain_scores_codex":[0.9999017,0.00001328236,0.00001166768,0.0000234502,0.00002771935,0.00002219846],"domain_scores_gemma":[0.9998701,0.00001525934,0.00005053288,0.00001697707,0.00001092286,0.00003616333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004374114,0.00001639597,0.0001861643,0.00001246097,0.000005634642,0.00004616752,0.000007552412,0.00001641216,0.9992369,0.00005864487,0.00001451274,0.0003554309],"study_design_scores_gemma":[0.00004985606,0.0007181357,0.03976744,0.00001596665,0.00004260529,0.0004499528,0.00007432556,0.0008991417,0.9567049,0.00009819286,0.001172234,0.000007346591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975967,0.0005499542,0.0007753098,0.00007631176,0.0000201116,0.00001534815,0.0002423495,0.00004098511,0.0006829484],"genre_scores_gemma":[0.9948754,0.0007206742,0.001144906,0.00005559792,0.000006577325,0.00003380717,0.0004194633,0.00001245383,0.002731304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277024,"threshold_uncertainty_score":0.004272103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975873353674452,"score_gpt":0.2949652901996619,"score_spread":0.2752065566629174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}