{"id":"W2606226990","doi":"10.1016/j.exphem.2017.04.004","title":"Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia","year":2017,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"Hyundai Hope On Wheels; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Epigenetics; Genome instability; DNA replication; DNA; Cancer research; Bromodeoxyuridine; Leukemia; Cell cycle; Human genome; Transplantation; DNA methylation; Cell biology; Genome; Molecular biology; Cell; DNA damage; Genetics; Cell growth; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669492,0.0001301782,0.0001878924,0.0002504894,0.0001267862,0.0003221987,0.0001511115,0.0001995504,0.002121714],"category_scores_gemma":[0.00041402,0.0001275256,0.0001217187,0.0002703711,0.0001201127,0.0001963456,0.0001159795,0.0003574329,0.0003347707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053344,"about_ca_system_score_gemma":0.0001446651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000808387,"about_ca_topic_score_gemma":0.000503895,"domain_scores_codex":[0.9998863,0.00002109913,0.00001148011,0.00003045981,0.00002606871,0.00002456166],"domain_scores_gemma":[0.9996804,0.00009387383,0.00008889474,0.00004807601,0.00003401224,0.00005482625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006240818,0.00004924643,0.003643361,0.00001539547,0.00001403239,0.00009063871,0.00003688001,0.0003156216,0.9933114,0.0001713905,0.0001109534,0.001617008],"study_design_scores_gemma":[0.00005360066,0.001559867,0.1519145,0.000005967324,0.00006043982,0.002034644,0.0001949637,0.005728967,0.8347675,0.0002158163,0.003448567,0.0000151718],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977027,0.0004572404,0.0005577986,0.0000262233,0.00001049038,0.000007548062,0.0007338214,0.0000330457,0.0004712334],"genre_scores_gemma":[0.9986986,0.0001105538,0.00016202,0.000008775241,0.000002411395,0.000006328996,0.0006682075,0.00000997139,0.0003331637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121714,"threshold_uncertainty_score":0.00709784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871651481668442,"score_gpt":0.2915916233242179,"score_spread":0.2728751085075335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}