{"id":"W2606226990","doi":"10.1016/j.exphem.2017.04.004","title":"Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia","year":2017,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"Hyundai Hope On Wheels; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Epigenetics; Genome instability; DNA replication; DNA; Cancer research; Bromodeoxyuridine; Leukemia; Cell cycle; Human genome; Transplantation; DNA methylation; Cell biology; Genome; Molecular biology; Cell; DNA damage; Genetics; Cell growth; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007469514,0.0001111177,0.0003138279,0.00004195591,0.00005093023,0.000005024275,0.000236616,0.0001161328,0.00001607702],"category_scores_gemma":[0.00004243942,0.0001181612,0.00007560181,0.00002504882,0.0002908549,0.000005957979,0.0002237673,0.00003947303,4.06497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007284919,"about_ca_system_score_gemma":0.00007533695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000141677,"about_ca_topic_score_gemma":0.0000498435,"domain_scores_codex":[0.9990363,0.00003007389,0.0004148209,0.0003025868,0.00007845226,0.0001378227],"domain_scores_gemma":[0.9985864,0.00002213762,0.0004363125,0.0008700158,0.000052503,0.00003261626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002340203,0.0002137304,0.006802272,0.00005567799,0.00002941203,0.000001889453,0.0003534363,0.000004005416,0.9893737,0.002195113,0.0002807616,0.0004559799],"study_design_scores_gemma":[0.0007751127,0.0003977463,0.01928982,0.0000321971,0.000007622269,0.00001526971,0.0001943381,0.00000414494,0.9789485,0.00007700613,0.0001679299,0.00009030863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952525,0.003402315,0.00002771582,0.00001248415,0.0001262115,0.0001970188,0.00004531936,0.000002238899,0.0009341315],"genre_scores_gemma":[0.9992647,0.00009332412,0.0004466772,0.00001981719,0.0000288047,0.00002387571,0.0001044572,0.00001208836,0.000006219384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01248755,"threshold_uncertainty_score":0.4818473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871651481668442,"score_gpt":0.2915916233242179,"score_spread":0.2728751085075335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}