{"id":"W2606254980","doi":"10.7554/elife.23872","title":"The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Structural Genomics Consortium; Université Laval; Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Hôtel-Dieu de Québec; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Genomics; Canada Research Chairs; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Krembil Foundation; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Ministero dello Sviluppo Economico; Cancer Research Society; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Leukemia and Lymphoma Society; European Commission; Pfizer","keywords":"Nucleosome; Ubiquitin; Chromatin; Histone; Cell biology; Ubiquitin ligase; DNA damage; Histone H2A; DNA repair; Biology; DNA; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006801835,0.0002870533,0.0002214119,0.0001471129,0.0002402261,0.0002651201,0.0003003233,0.0003031771,0.0007980589],"category_scores_gemma":[0.0000591635,0.0001334172,0.0001765881,0.0001039164,0.0002246,0.00032607,0.0001916413,0.0002176619,0.0005535751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923707,"about_ca_system_score_gemma":0.0001448408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007633403,"about_ca_topic_score_gemma":0.001184946,"domain_scores_codex":[0.9999628,0.000003237633,0.000001776515,0.00001304687,0.00001278449,0.000006413198],"domain_scores_gemma":[0.9999725,0.000002386603,0.0000104967,0.000003192671,0.000003295702,0.000008112503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008386184,0.00001300207,0.001148787,0.00004901247,0.000006864323,0.0002596382,0.00001943374,0.0007807654,0.9889007,0.001916644,0.000177227,0.006644215],"study_design_scores_gemma":[0.00003096416,0.0002649203,0.01470955,0.00001763523,0.00001746266,0.003453192,0.00009933404,0.01675412,0.9187022,0.003116238,0.04280086,0.00003356409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.948862,0.003912855,0.04055618,0.0001706654,0.00007686521,0.00003058189,0.0003837595,0.0005523612,0.005454632],"genre_scores_gemma":[0.9696265,0.001102399,0.02473119,0.00004134236,0.00001969453,0.0000157588,0.0006963807,0.00006096478,0.003705797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007980589,"threshold_uncertainty_score":0.002669752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527018924300957,"score_gpt":0.303279459595314,"score_spread":0.2780092703523045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}