{"id":"W2606278400","doi":"10.1038/srep46263","title":"Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; IXICO; Karolinska Institutet; Alzheimerfonden; Servier; Vetenskapsrådet; Eisai; H. Lundbeck A/S; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Atrophy; Temporal lobe; Hippocampal formation; Neuroscience; Clinical Dementia Rating; Cognition; Alzheimer's disease; Posterior cortical atrophy; Pathology; Hippocampus; Disease; Psychology; Medicine; Dementia; Epilepsy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002852485,0.0003450791,0.0002860637,0.001535789,0.0003866184,0.000666947,0.0004062463,0.000382853,0.0006453376],"category_scores_gemma":[0.004745116,0.0001746837,0.0002667878,0.001401412,0.0003850346,0.0009104438,0.0005851301,0.000431055,0.0002786599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322877,"about_ca_system_score_gemma":0.0005227537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004848177,"about_ca_topic_score_gemma":0.006998608,"domain_scores_codex":[0.9995758,0.0001405515,0.00005964107,0.0001057762,0.00008135635,0.00003679394],"domain_scores_gemma":[0.99803,0.0003231301,0.0007890004,0.0001973709,0.0004858538,0.0001745424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003001411,0.0000616294,0.9701347,0.00004611626,0.00008114269,0.00005655265,0.0003059476,0.0001214814,0.0007127777,0.00006797212,0.0001717185,0.02793995],"study_design_scores_gemma":[0.000007843148,0.0002670121,0.9974518,0.00002936577,0.00006718233,0.0003625817,0.0002242621,0.0004746802,0.0002402807,0.0002827351,0.0005822466,0.000009951385],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916512,0.005256899,0.00110576,0.0001560637,0.00001585365,0.0000486868,0.0005374785,0.00001786327,0.001210191],"genre_scores_gemma":[0.9941737,0.002177073,0.002182687,0.00002747048,0.00001939814,0.00006333397,0.0009923562,0.00000636709,0.0003575151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004848177,"threshold_uncertainty_score":0.01508558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163044636224566,"score_gpt":0.3857861249702367,"score_spread":0.334155678607991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}