{"id":"W2606278400","doi":"10.1038/srep46263","title":"Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; IXICO; Karolinska Institutet; Alzheimerfonden; Servier; Vetenskapsrådet; Eisai; H. Lundbeck A/S; Genentech; Stiftelsen för Strategisk Forskning; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Åke Wiberg Stiftelse; Hjärnfonden; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Atrophy; Temporal lobe; Hippocampal formation; Neuroscience; Clinical Dementia Rating; Cognition; Alzheimer's disease; Posterior cortical atrophy; Pathology; Hippocampus; Disease; Psychology; Medicine; Dementia; Epilepsy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00119596,0.00009142797,0.0002432748,0.0001033461,0.0002617412,0.00007509153,0.00008970597,0.00002991129,0.0001372646],"category_scores_gemma":[0.0006160163,0.00007180316,0.0001359026,0.00007278237,0.0008188112,0.00006795589,0.00006703391,0.0000873765,0.00000287783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008158299,"about_ca_system_score_gemma":0.000245674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005479376,"about_ca_topic_score_gemma":0.00002236932,"domain_scores_codex":[0.9982951,0.00004574436,0.0004566844,0.0004736445,0.0005646601,0.0001641542],"domain_scores_gemma":[0.9980394,0.00009745965,0.0003887551,0.0009640044,0.0002852024,0.0002251869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001395666,0.0004407418,0.9911522,0.0001036651,0.00005074658,0.0001571362,0.00001077281,2.955206e-7,0.0005989727,0.00004287057,0.0003461027,0.006956896],"study_design_scores_gemma":[0.0004178404,0.0002507386,0.9939974,0.0001120618,0.0002162468,0.00000864683,0.00001590561,0.00009176237,0.003365299,0.0003890825,0.001073776,0.00006126775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969585,0.00008367076,0.0005516765,0.0005495927,0.000414983,0.0005831085,0.00002975536,0.00001101027,0.0008177036],"genre_scores_gemma":[0.9991057,0.000004306958,0.00008926399,0.00001494281,0.00006364033,0.00003569103,0.0000709063,0.00000787899,0.0006076636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006895628,"threshold_uncertainty_score":0.3016944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163044636224566,"score_gpt":0.3857861249702367,"score_spread":0.334155678607991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}