{"id":"W2606281512","doi":"10.1021/jacs.7b01083","title":"Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Scripps Research Institute","keywords":"Choline acetyltransferase; Chemistry; Protein kinase C; Acetylcholine; Mechanism (biology); Cell biology; Acetyltransferase; Cholinergic; Enzyme activator; Biochemistry; Enzyme; Neuroscience; Pharmacology; Gene; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741437,0.0007228891,0.0003113387,0.0004421571,0.0002354173,0.0004201503,0.000296425,0.000409012,0.00122511],"category_scores_gemma":[0.0001464799,0.0001470223,0.0004701604,0.000364042,0.0002641434,0.0005122506,0.000266561,0.0005054154,0.0006109372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006996398,"about_ca_system_score_gemma":0.0005197929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009212927,"about_ca_topic_score_gemma":0.001439094,"domain_scores_codex":[0.99991,0.00001150372,0.000007131372,0.0000245326,0.00002157966,0.00002522364],"domain_scores_gemma":[0.9999074,0.00001447369,0.00002076893,0.00001232172,0.00001584142,0.00002918506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130366,0.00001217352,0.0002095639,0.00008096198,0.000008010193,0.0001468761,0.00001391896,0.0000702472,0.9967038,0.0002030551,0.00001508664,0.002423383],"study_design_scores_gemma":[0.0000112053,0.0001258219,0.0021076,0.000006453613,0.0000193468,0.0002106096,0.00002062898,0.0001656359,0.9951663,0.00008198294,0.002078202,0.000006284996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9334743,0.02693712,0.03026569,0.0004927719,0.0001572739,0.0002966351,0.001565153,0.0001229174,0.006688206],"genre_scores_gemma":[0.9690314,0.01199887,0.0106741,0.0001326732,0.00005473528,0.0001088579,0.00130187,0.00002205162,0.006675478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122511,"threshold_uncertainty_score":0.005076289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009631594041547464,"score_gpt":0.2679485847203136,"score_spread":0.2583169906787661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}