{"id":"W2606300507","doi":"10.1101/124438","title":"The role of <i>Cdx2</i> as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Fundamental Research Funds for the Central Universities; Zhejiang University","keywords":"Inner cell mass; Biology; Trophoblast; Transcription factor; Homeobox protein NANOG; Cell biology; Embryonic stem cell; CDX2; Repressor; Blastocyst; Gene regulatory network; Nanog Homeobox Protein; Induced pluripotent stem cell; Cell fate determination; Genetics; Gene; Embryo; Gene expression; Embryogenesis; Placenta; Homeobox","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461051,0.0002718623,0.0001795612,0.0001594225,0.0002149308,0.0004892278,0.0002214004,0.0001946566,0.001526458],"category_scores_gemma":[0.0001366684,0.0001867466,0.0001675318,0.00009951837,0.0002592902,0.0002152747,0.0003078449,0.0003901299,0.0003283112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003377163,"about_ca_system_score_gemma":0.0002063139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008492869,"about_ca_topic_score_gemma":0.001520811,"domain_scores_codex":[0.9998342,0.00001548119,0.000009821046,0.0000763816,0.00004179591,0.0000222832],"domain_scores_gemma":[0.9998947,0.0000189122,0.0000292321,0.00001319349,0.00001405573,0.00002987775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003521574,0.000004102719,0.001023633,0.00002284933,0.000004729985,0.00003151837,0.0000120469,0.0000967466,0.997584,0.0002369341,0.00007932563,0.0008688419],"study_design_scores_gemma":[0.00001202301,0.00005024214,0.04746751,0.00001318784,0.00001770066,0.0002320509,0.00004966613,0.004371905,0.9416981,0.0001991446,0.005880779,0.000007617158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815778,0.002050883,0.01146231,0.0001698286,0.00004393614,0.00001784501,0.0009568494,0.0002213414,0.003499284],"genre_scores_gemma":[0.991211,0.0003518376,0.002667318,0.0001120106,0.00001405436,0.00002578222,0.001165991,0.00007300956,0.004378917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526458,"threshold_uncertainty_score":0.005106449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087948434698256,"score_gpt":0.2202685795763668,"score_spread":0.2093890952293843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}