{"id":"W2606367272","doi":"10.1016/j.clml.2017.03.256","title":"Updated Results from ASPIRE and ENDEAVOR, Randomized, Open-Label, Multicenter Phase 3 Studies of Carfilzomib in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)","year":2017,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Leukemia & Lymphoma Society of Canada","funders":"","keywords":"Carfilzomib; Multiple myeloma; Medicine; Open label; Refractory (planetary science); Oncology; Phase (matter); Randomized controlled trial; Internal medicine; Lenalidomide; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007814894,0.001122839,0.002932822,0.0007937182,0.0003856001,0.002171602,0.001058051,0.001424934,0.005455312],"category_scores_gemma":[0.01063954,0.0005473376,0.00370761,0.001090451,0.0005170528,0.001540307,0.0007740684,0.002197621,0.0008900499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001273002,"about_ca_system_score_gemma":0.002027242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001828351,"about_ca_topic_score_gemma":0.007306429,"domain_scores_codex":[0.9971094,0.001505557,0.0003667776,0.0002434379,0.0005203499,0.0002544222],"domain_scores_gemma":[0.9900486,0.004312861,0.003159253,0.0004821364,0.00110645,0.0008906919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5805645,0.003156008,0.02032921,0.007709658,0.02748604,0.0002761291,0.000323869,0.001781239,0.01015632,0.0005644289,0.06642842,0.2812242],"study_design_scores_gemma":[0.6456039,0.05654072,0.1493509,0.001468429,0.06393328,0.0009121189,0.0002539849,0.001142163,0.004285737,0.001235709,0.07507964,0.0001934785],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6394722,0.2181268,0.005258444,0.02487027,0.004419633,0.005598113,0.07713341,0.001470833,0.02365024],"genre_scores_gemma":[0.8705949,0.04044724,0.008807831,0.01889371,0.002859102,0.003314081,0.04864224,0.0002321304,0.006208672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007814894,"threshold_uncertainty_score":0.04132962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08929741469129712,"score_gpt":0.4036022536948979,"score_spread":0.3143048390036008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}