{"id":"W2606376939","doi":"10.1016/j.yexcr.2017.04.024","title":"CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein","year":2017,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; University of Surrey; Natural Sciences and Engineering Research Council of Canada; Alzheimer Society","keywords":"Biology; Retromer; Endosome; Transmembrane protein; Cell biology; Transmembrane domain; Amyloid precursor protein; Golgi apparatus; Gene; Protein family; Proteasome; Proteolysis; Genetics; Biochemistry; Receptor; Alzheimer's disease; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001068384,0.0002224457,0.0003426791,0.0001478569,0.0008632534,0.0001720419,0.001369075,0.0001726131,0.001148018],"category_scores_gemma":[0.0003579725,0.000159554,0.000163417,0.0003993972,0.0006805468,0.0001539266,0.001399455,0.0009413171,0.0004390511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342648,"about_ca_system_score_gemma":0.0003739263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00274019,"about_ca_topic_score_gemma":0.00002663585,"domain_scores_codex":[0.9953422,0.0002335188,0.0002922219,0.0006840092,0.002510395,0.0009376513],"domain_scores_gemma":[0.9970751,0.00004488544,0.00009732146,0.001997813,0.0003707519,0.0004140852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007868214,0.0006411635,0.001122834,0.0001301837,0.00002701003,0.00002056754,0.001607255,2.082297e-7,0.7949457,0.00003127489,0.2002728,0.0004141692],"study_design_scores_gemma":[0.001469318,0.0007451512,0.002081459,0.0001340947,0.000004647064,0.000004128819,0.003527989,0.00002775185,0.9337056,0.00002500704,0.05812673,0.0001481588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9113653,0.001979853,0.000001464403,0.005246558,0.0001239563,0.003622723,0.0000225449,0.00002432285,0.07761327],"genre_scores_gemma":[0.9081258,0.00002012985,0.000267145,0.0002671106,0.0001058567,0.0003655092,0.000008054272,0.00006276502,0.09077761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1421461,"threshold_uncertainty_score":0.999765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07033673584362604,"score_gpt":0.4034680369796196,"score_spread":0.3331313011359936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}