{"id":"W2606397279","doi":"10.1038/ncomms15000","title":"MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Intellectual and Developmental Disabilities Research Center","keywords":"Osteocyte; Osteoblast; Cell biology; microRNA; Cellular differentiation; Sclerostin; Transforming growth factor; Bone morphogenetic protein 2; Chemistry; Biology; Signal transduction; Wnt signaling pathway; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787816,0.0004113747,0.0003884159,0.0003380722,0.0002139787,0.0004534202,0.0001926639,0.0002313526,0.001384226],"category_scores_gemma":[0.0001568969,0.0002325573,0.0003437456,0.000155252,0.000268049,0.0001311294,0.0003315902,0.0004942505,0.0007189343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002868776,"about_ca_system_score_gemma":0.0003854348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005153057,"about_ca_topic_score_gemma":0.0008052027,"domain_scores_codex":[0.999818,0.00002424729,0.00001691986,0.00003635758,0.00007295957,0.00003154292],"domain_scores_gemma":[0.9998871,0.00001577615,0.00003535219,0.000008734557,0.00001528603,0.0000377046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009460646,0.00001074074,0.0001099528,0.00002896249,0.000003809359,0.00005403072,0.000009198901,0.00003173922,0.9987234,0.00005682907,0.00004280496,0.0008338548],"study_design_scores_gemma":[0.00003184043,0.0001753134,0.004541571,0.000008245342,0.00002392517,0.0003432605,0.00002647624,0.0006095153,0.9880216,0.00007188832,0.006139816,0.000006573483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759193,0.008413471,0.007747194,0.0003082762,0.0001615217,0.00007575304,0.0007523414,0.0006323495,0.005989783],"genre_scores_gemma":[0.9887108,0.002298942,0.005184093,0.0001260857,0.00002742525,0.00006059593,0.0004306074,0.0001000777,0.003061434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384226,"threshold_uncertainty_score":0.004630685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277073989414522,"score_gpt":0.2835250140823481,"score_spread":0.2707542741882029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}