{"id":"W2606398981","doi":"10.1016/s0140-6736(17)30570-6","title":"Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":446,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Medicine; Crohn's disease; Internal medicine; Placebo; Gastroenterology; Population; Ileitis; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001432272,0.001656929,0.004609535,0.0004320337,0.0003863371,0.0009861388,0.0009368338,0.002135506,0.004762874],"category_scores_gemma":[0.001245141,0.00075463,0.002102486,0.0004193744,0.00133839,0.00102096,0.0004425847,0.003419404,0.0009831341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005882428,"about_ca_system_score_gemma":0.0008349482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007730964,"about_ca_topic_score_gemma":0.001360822,"domain_scores_codex":[0.9994727,0.0002316548,0.00003648929,0.00008044447,0.00005129949,0.0001274702],"domain_scores_gemma":[0.9992428,0.0002188779,0.000136787,0.00006939277,0.00004534929,0.0002868115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9766173,0.004764945,0.0004755332,0.0005454163,0.0005728569,0.00004507688,0.00003858176,0.0001765208,0.00347789,0.00004267802,0.0005250858,0.01271818],"study_design_scores_gemma":[0.9406075,0.0569425,0.001475263,0.00001683687,0.0002250016,0.00002298814,0.0000120004,0.0001116063,0.0002552823,0.00004127086,0.0002805795,0.000009038873],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854475,0.007889652,0.0006813276,0.0006967794,0.000718475,0.001902151,0.0008296015,0.0001581908,0.001676281],"genre_scores_gemma":[0.9844118,0.005066372,0.001390766,0.00149208,0.0008433077,0.002212344,0.001321611,0.00003159445,0.003230191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004762874,"threshold_uncertainty_score":0.01593345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638400138012186,"score_gpt":0.2788584941830377,"score_spread":0.2624744928029158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}