{"id":"W2606505978","doi":"10.18433/j36c8n","title":"Does Evolocumab, as a PCSK9 Inhibitor, Ameliorate the Lipid Profile in Familial Hypercholesterolemia Patients? A Meta-Analysis of Randomized Controlled Trials","year":2017,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Medical Research Development","keywords":"Evolocumab; PCSK9; Alirocumab; Familial hypercholesterolemia; Kexin; Meta-analysis; Internal medicine; Medicine; Placebo; LDL receptor; Endocrinology; Lipoprotein; Pharmacology; Cholesterol; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008644043,0.001946451,0.01463634,0.002663282,0.0005162851,0.002162393,0.001348958,0.001824136,0.002577337],"category_scores_gemma":[0.01140891,0.0009675818,0.03113759,0.003479689,0.0004966183,0.001116602,0.0007692013,0.001963627,0.0002336902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001410205,"about_ca_system_score_gemma":0.001092151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003606575,"about_ca_topic_score_gemma":0.006417248,"domain_scores_codex":[0.9946626,0.002777912,0.001180825,0.0007390745,0.0004277808,0.0002116451],"domain_scores_gemma":[0.9923085,0.005260333,0.001326349,0.0003670342,0.0005212197,0.0002166248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.02236268,0.00005738132,0.007674224,0.06581906,0.8935702,0.0001012528,0.00003412109,0.0005582009,0.0003781727,0.00006208549,0.0004281589,0.008954613],"study_design_scores_gemma":[0.002640731,0.0004411127,0.005306721,0.001864473,0.9886824,0.00004897871,0.00001776349,0.0002149384,0.0001137544,0.000096004,0.0005602818,0.00001286406],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03916669,0.9578028,0.0007031228,0.000414706,0.0003722874,0.0002247894,0.0008533692,0.00004290279,0.0004193396],"genre_scores_gemma":[0.6898282,0.3029341,0.001871982,0.001661731,0.0006022681,0.0006468903,0.001744596,0.00005010404,0.0006601147],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01463634,"threshold_uncertainty_score":0.04571462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2878359085137892,"score_gpt":0.5086206952179305,"score_spread":0.2207847867041413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}