{"id":"W2606542540","doi":"10.1093/jnci/djw258","title":"Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Ontario Institute for Cancer Research; Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Single-nucleotide polymorphism; Imputation (statistics); Haplotype; Cohort; Genome-wide association study; Prostate cancer; Oncology; Medicine; Genotype; SNP; Odds ratio; Genotyping; Linkage disequilibrium; Internal medicine; Cancer; Biology; Genetics; Gene; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000401714,0.000289868,0.0002236269,0.0004713725,0.0001971988,0.000286357,0.0002633392,0.0003265291,0.002359608],"category_scores_gemma":[0.001330699,0.0001164092,0.000272943,0.0006016768,0.000282723,0.0001129681,0.0002291942,0.0003405975,0.0001790869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114762,"about_ca_system_score_gemma":0.0002282236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002113741,"about_ca_topic_score_gemma":0.002379874,"domain_scores_codex":[0.9997919,0.00004179924,0.00001761299,0.00007866382,0.00004347648,0.00002651065],"domain_scores_gemma":[0.9990745,0.000292302,0.0003956585,0.00005746132,0.00004649167,0.0001337053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005785575,0.00004533861,0.9878293,0.00004725507,0.0002510297,0.0006538436,0.00007546708,0.000255565,0.004216038,0.00007127658,0.0002344239,0.005741875],"study_design_scores_gemma":[0.00004498558,0.000154767,0.9952202,0.00001453637,0.00023033,0.002483084,0.00003583643,0.0003660234,0.0007899232,0.0001808759,0.0004726569,0.000006660212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983819,0.0006158423,0.0002991966,0.00006057478,0.000007863574,0.000008015212,0.0003383933,0.00002042494,0.000267934],"genre_scores_gemma":[0.999283,0.0001718327,0.0002322624,0.00002176225,0.00001474731,0.00000259565,0.0001634195,0.000002806562,0.000107466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359608,"threshold_uncertainty_score":0.007893622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05004372352302052,"score_gpt":0.352855809946327,"score_spread":0.3028120864233065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}