{"id":"W2606615303","doi":"10.1021/acs.biochem.6b01276","title":"The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the p<i>K</i><sub>a</sub> of the Distal Histidine","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme-mediated dye degradation","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Fundação para a Ciência e a Tecnologia; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Catalase; Heme; Chemistry; Adduct; Peroxidase; Enzyme; Histidine; Protonation; Stereochemistry; Biochemistry; Organic chemistry; Ion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000230825,0.000117888,0.0001170388,0.00000268929,0.0003220499,0.00004319236,0.0007539053,0.00009781517,0.000007127595],"category_scores_gemma":[0.0003384851,0.00003375795,0.00006603437,0.0001193132,0.0003507253,0.00005435447,0.0001186368,0.000119255,0.000001340355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002389072,"about_ca_system_score_gemma":0.00001402857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007212259,"about_ca_topic_score_gemma":0.001067084,"domain_scores_codex":[0.9992028,0.00004960714,0.0001454633,0.0001876385,0.0002493979,0.0001650165],"domain_scores_gemma":[0.9990903,0.0002041353,0.0003074154,0.0003172753,0.00005040734,0.00003052625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001969075,0.00008649493,0.002940133,0.00001293333,0.000006535216,6.202188e-7,0.00004851763,1.841059e-7,0.9884391,0.000002336017,0.003122921,0.005320542],"study_design_scores_gemma":[0.00008963545,0.00002377319,0.07899998,0.00002611125,0.000009232293,0.000001853965,0.0000976132,0.00002653899,0.9202461,0.00001390375,0.0003965971,0.00006867637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947226,0.0002357578,1.359195e-7,0.004037315,0.00006055742,0.0001332794,0.0007236525,0.00000876988,0.00007793694],"genre_scores_gemma":[0.9995273,0.00008809545,7.66676e-7,0.00004497183,0.00006896793,0.00001598015,0.0001533569,0.000001098751,0.00009944255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07605985,"threshold_uncertainty_score":0.247698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033063404452842,"score_gpt":0.2035368096802339,"score_spread":0.1932061756357055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}