{"id":"W2606731929","doi":"10.1016/j.jaad.2017.01.052","title":"Long-term safety and tolerability of apremilast in patients with psoriasis: Pooled safety analysis for ≥156 weeks from 2 phase 3, randomized, controlled trials (ESTEEM 1 and 2)","year":2017,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Cilag; LEO Pharma; Astellas Pharma; Regeneron Pharmaceuticals; Celgene; GlaxoSmithKline; Biogen; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Apremilast; Tolerability; Psoriasis; Randomized controlled trial; Safety profile; Pooled analysis; Adverse effect; Dermatology; Internal medicine; Meta-analysis; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002046409,0.0002752096,0.006877405,0.0002971733,0.0001806975,0.00001291691,0.000444566,0.0002215205,0.00002818083],"category_scores_gemma":[0.001908247,0.0001466783,0.0009221521,0.0001377516,0.001538479,0.0001343693,0.000101388,0.0002737234,2.771129e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000302715,"about_ca_system_score_gemma":0.00007262369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000675861,"about_ca_topic_score_gemma":0.00002933394,"domain_scores_codex":[0.9945243,0.002536753,0.002345086,0.0002518981,0.00009443612,0.0002475148],"domain_scores_gemma":[0.9875861,0.004365759,0.007576162,0.0002875728,0.0001367137,0.00004773624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4116991,0.0003880316,0.5661781,0.00002134262,0.0116185,0.000001894218,0.0001859776,0.000008146313,0.00148659,0.00002759053,0.00001387733,0.008370822],"study_design_scores_gemma":[0.3520493,0.0003019884,0.6342999,0.00007632233,0.009600473,0.00003751338,0.0000614442,0.00001024767,0.003303476,0.0001142808,0.00003265684,0.0001124571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934921,0.002795713,0.0003636456,0.001654818,0.0001633682,0.001101431,0.0004104828,0.000003189567,0.00001520199],"genre_scores_gemma":[0.9986379,0.000952722,0.0002377024,0.00007834099,0.00002587266,0.00002020416,0.00002103452,0.00001074356,0.00001554976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06812172,"threshold_uncertainty_score":0.5981366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682669124010412,"score_gpt":0.2979934696584649,"score_spread":0.2811667784183608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}