{"id":"W2606822414","doi":"10.7554/elife.27713","title":"Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Lustgarten Foundation; Ludwig Center for Molecular Oncology; National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; Stand Up To Cancer; Australian Government; Ludwig Institute for Cancer Research; York University; Howard Hughes Medical Institute","keywords":"Glutamine; Glutaminase; Catabolism; Biochemistry; Biology; Cystine; Metabolism; Glutaminolysis; Cell biology; Amino acid; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007360023,0.0001472325,0.0001474259,0.00002676084,0.0002271762,0.00005444921,0.00008188064,0.00008281172,0.00002911713],"category_scores_gemma":[0.00003205575,0.0001468747,0.00004706525,0.0000150182,0.000118304,0.000007542872,0.0001815561,0.00004802674,0.00001476187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358755,"about_ca_system_score_gemma":0.00002222428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001490224,"about_ca_topic_score_gemma":0.000239765,"domain_scores_codex":[0.9992042,0.00001465697,0.0001230125,0.000332097,0.0001214708,0.0002045747],"domain_scores_gemma":[0.9993846,0.000004002638,0.00008001534,0.0003557116,0.00001807581,0.0001576027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005581839,0.00002595391,0.000977335,0.000008017915,0.00002029336,0.000002339453,0.00007537242,0.00001184278,0.9820235,0.000003058387,0.004758375,0.01203814],"study_design_scores_gemma":[0.00058827,0.00008822577,0.06080915,0.00001675534,0.00002517703,0.000007510724,0.00005432353,0.00001302337,0.8308157,0.000001853855,0.1074043,0.0001757447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962988,0.002128903,0.0001053112,0.0003543713,0.0005938373,0.0001552524,0.000241247,0.000008793323,0.0001134453],"genre_scores_gemma":[0.9923503,0.003811117,0.0003739562,0.0006779691,0.001747391,0.00002665111,0.00005530794,0.00002045827,0.0009368391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1512078,"threshold_uncertainty_score":0.5989376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610244626569208,"score_gpt":0.239310638031338,"score_spread":0.2317003934047688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}