{"id":"W2606850629","doi":"10.1016/j.heliyon.2017.e00291","title":"Self-assembled particulate PsaA as vaccine against Streptococcus pneumoniae infection","year":2017,"lang":"en","type":"article","venue":"Heliyon","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Microbiology; Antigenicity; Bacterial adhesin; Streptococcus pneumoniae; Virulence; Antigen; Escherichia coli; Biology; Monoclonal antibody; Polyhydroxybutyrate; Serotype; Chemistry; Antibody; Bacteria; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240123,0.0002859437,0.0003277905,0.000226211,0.00008505645,0.0002233906,0.000241064,0.0004073867,0.0007033214],"category_scores_gemma":[0.00009733271,0.000118779,0.0003137163,0.0001431684,0.000134053,0.0002041996,0.0002543406,0.0004835524,0.0003155256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542583,"about_ca_system_score_gemma":0.0001591004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564161,"about_ca_topic_score_gemma":0.0003942737,"domain_scores_codex":[0.9998932,0.00001580715,0.000006462641,0.00001913968,0.00004017579,0.00002521206],"domain_scores_gemma":[0.999945,0.000005727545,0.00001313405,0.000005308385,0.00001350742,0.00001737228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005448779,0.0000725299,0.0001110064,0.00006323009,0.000009581177,0.00003530805,0.000009985791,0.000234296,0.9971066,0.00008026337,0.00004225817,0.002180444],"study_design_scores_gemma":[0.00004065608,0.003227231,0.002860343,0.00002751696,0.00006932134,0.0003046616,0.00003578796,0.004312283,0.9826278,0.0001290166,0.006353873,0.0000115052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889289,0.002345577,0.007025856,0.00008969526,0.0001068746,0.00006715399,0.0001561462,0.00009758797,0.001182228],"genre_scores_gemma":[0.990393,0.001173686,0.005392,0.00008441487,0.00002643218,0.00003860705,0.0004668949,0.00001622208,0.002408774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007033214,"threshold_uncertainty_score":0.002352893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658837959289823,"score_gpt":0.3059802547841649,"score_spread":0.2893918751912666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}