{"id":"W2606874422","doi":"10.1016/j.omtn.2017.04.017","title":"Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FI T45","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Entry inhibitor; Epitope; Bifunctional; Antibody; Glycoprotein; Cell fusion; Chemistry; Fusion protein; Cell biology; Virology; Cell; Viral entry; Biology; Virus; Biochemistry; Immunology; Viral replication; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001132386,0.0001463358,0.0001615979,0.00004362851,0.0004016675,0.00003603812,0.0004035645,0.0001511262,0.001343838],"category_scores_gemma":[0.00002999995,0.00009567601,0.0001511546,0.00004964424,0.0003232177,0.0000843366,0.0001106827,0.0001698852,0.0007671075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000298603,"about_ca_system_score_gemma":0.00006274383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001926763,"about_ca_topic_score_gemma":0.000001738466,"domain_scores_codex":[0.9991308,0.0001458366,0.0001658771,0.0002153956,0.0000897672,0.0002522908],"domain_scores_gemma":[0.9990482,0.0000125297,0.0001511454,0.000692544,0.00007116589,0.00002444447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002203509,0.0001886674,0.01477799,0.000004115338,0.0002742815,0.000005967931,0.0001971915,5.117657e-7,0.9695273,0.0002656712,0.0003423957,0.01419557],"study_design_scores_gemma":[0.00220186,0.0001518259,0.186253,0.0000230331,0.00001558185,0.00001341116,0.0000215583,0.000001941161,0.7365661,0.00009118412,0.0745535,0.0001069229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950531,0.0004757103,0.0002826166,0.001906414,0.0004843739,0.0003012787,0.0001044446,0.00002428222,0.001367847],"genre_scores_gemma":[0.9958851,0.0001367211,0.00002428138,0.0002352424,0.00004617228,0.00002955032,0.0001697589,0.00002245518,0.003450698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2329611,"threshold_uncertainty_score":0.9995691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020538142269828,"score_gpt":0.2346796224263696,"score_spread":0.2244742410036713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}