{"id":"W2606874422","doi":"10.1016/j.omtn.2017.04.017","title":"Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FI T45","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Entry inhibitor; Epitope; Bifunctional; Antibody; Glycoprotein; Cell fusion; Chemistry; Fusion protein; Cell biology; Virology; Cell; Viral entry; Biology; Virus; Biochemistry; Immunology; Viral replication; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775165,0.0002082533,0.0001192313,0.0001465536,0.0001221273,0.0002641809,0.000169865,0.0002301226,0.0007446546],"category_scores_gemma":[0.0001931036,0.00006334894,0.0001190729,0.0001506616,0.0000901492,0.0001783107,0.0001076954,0.0003595674,0.0002175175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671942,"about_ca_system_score_gemma":0.0002721878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675399,"about_ca_topic_score_gemma":0.001069648,"domain_scores_codex":[0.9999013,0.00001578185,0.000005450745,0.00001221223,0.00003883856,0.00002634784],"domain_scores_gemma":[0.9999568,0.000007551866,0.00000742042,0.000004807038,0.00001342729,0.00000989772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003704533,0.00001839126,0.000105092,0.0000131111,0.0000023896,0.00001844416,0.00001004663,0.0001323734,0.9980651,0.0002335407,0.00005090975,0.001313602],"study_design_scores_gemma":[0.000004127361,0.00005744869,0.0004183248,0.000001387941,0.000003502324,0.0000445449,0.000006777271,0.0009952402,0.9968318,0.00001825429,0.001616256,0.000002307569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857013,0.0009408438,0.011077,0.0001085011,0.00002193063,0.00005584427,0.0004332616,0.00006702163,0.001594223],"genre_scores_gemma":[0.9869888,0.0005373973,0.008726619,0.00004389989,0.000003723013,0.00002383488,0.001183293,0.00001699673,0.002475387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675399,"threshold_uncertainty_score":0.003331363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020538142269828,"score_gpt":0.2346796224263696,"score_spread":0.2244742410036713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}