{"id":"W2606928709","doi":"10.1371/journal.pgen.1006735","title":"Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene duplication; Biology; Functional divergence; Genetics; Gene; Complementation; Pleiotropy; Subfunctionalization; Human evolutionary genetics; Evolutionary biology; Gene family; Computational biology; Phylogenetics; Genome; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003196654,0.0001483785,0.0001341579,0.00004147659,0.0001045426,0.00003317946,0.000470091,0.0001711629,0.000009355301],"category_scores_gemma":[0.00006876377,0.0001115496,0.00003945934,0.0001405547,0.0001095629,0.0000118624,0.0001017529,0.0001502021,0.000003690678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000213505,"about_ca_system_score_gemma":0.0001035348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002747753,"about_ca_topic_score_gemma":0.0004525888,"domain_scores_codex":[0.9987963,0.0002180568,0.0002872518,0.0002659344,0.000214459,0.0002180253],"domain_scores_gemma":[0.9990647,0.000008074909,0.0001736446,0.0006644192,0.0000695294,0.00001956826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003245201,0.001676653,0.3848781,0.0001374404,0.00004626207,0.00001673024,0.004910213,0.007869137,0.5979369,0.0014778,0.0003293016,0.0003969912],"study_design_scores_gemma":[0.002966472,0.0006859771,0.7994205,0.0001312404,0.00002410425,0.00000833275,0.004314159,0.008415825,0.1795036,0.001730875,0.002316252,0.0004826683],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964398,0.001586283,0.0004463552,0.0003142473,0.00007616764,0.000599117,0.00002150409,0.000004173532,0.0005123978],"genre_scores_gemma":[0.998879,0.000195956,0.0004134339,0.0001625719,0.00008322443,0.00009480871,0.0001085683,0.00001779146,0.00004469003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4184332,"threshold_uncertainty_score":0.454886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062531931195867,"score_gpt":0.2525021570572574,"score_spread":0.2318768377452987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}