{"id":"W2606928709","doi":"10.1371/journal.pgen.1006735","title":"Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene duplication; Biology; Functional divergence; Genetics; Gene; Complementation; Pleiotropy; Subfunctionalization; Human evolutionary genetics; Evolutionary biology; Gene family; Computational biology; Phylogenetics; Genome; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005443043,0.0002125458,0.0002247395,0.0004425348,0.0003665503,0.0004561009,0.0003419617,0.0003621318,0.0008743043],"category_scores_gemma":[0.00156001,0.0001495685,0.0002218375,0.000256796,0.0007464198,0.0005853525,0.0004325927,0.0006370792,0.00009897589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006958641,"about_ca_system_score_gemma":0.0002805962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003630273,"about_ca_topic_score_gemma":0.0006467624,"domain_scores_codex":[0.9997105,0.00009865831,0.00001617476,0.00008776761,0.00006110885,0.00002570678],"domain_scores_gemma":[0.9993654,0.0002890091,0.000107515,0.0001447298,0.0000374112,0.00005607236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004751007,0.000133028,0.01799785,0.00007734595,0.0000835469,0.000245587,0.0001842808,0.004715212,0.9579395,0.00443508,0.0000866222,0.0136269],"study_design_scores_gemma":[0.0001934134,0.001920253,0.3992609,0.00004448487,0.000227209,0.002850919,0.001101725,0.08536268,0.4822294,0.01867693,0.007952643,0.0001793516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996392,0.000121655,0.002678679,0.00006534135,0.000003777571,0.00000738899,0.0000349519,0.00003189395,0.0006642919],"genre_scores_gemma":[0.9968818,0.0001095199,0.002600249,0.00004223861,0.000003152718,0.00002229794,0.00006990299,0.0000214225,0.0002493767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008743043,"threshold_uncertainty_score":0.005048931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062531931195867,"score_gpt":0.2525021570572574,"score_spread":0.2318768377452987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}